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Ryan Reynolds Announces More to Parkinson’s® Campaign

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Ryan Reynolds Announces More to Parkinson’s® Campaign
News

News

Ryan Reynolds Announces More to Parkinson’s® Campaign

2024-08-14 20:04 Last Updated At:20:21

SAN DIEGO--(BUSINESS WIRE)--Aug 14, 2024--

Ryan Reynolds, a world-renowned actor/entrepreneur and Parkinson’s disease advocate, with Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) today announced the launch of a multi-faceted disease education campaign, More to Parkinson’s®, to raise awareness among caregivers, patients and their care providers about a common, yet under-recognized aspect of Parkinson’s disease – Parkinson’s-related hallucinations and delusions.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20240801386480/en/

Notably, around half of the people living with Parkinson’s disease may develop hallucinations or delusions over the course of their disease, but up to 90% of people currently do not proactively tell their physicians about these symptoms. 1-3 By sharing their experiences caring for Ryan’s father, James “Jim” Reynolds, who passed away nearly a decade ago, Ryan and his mother Tammy, aim to raise awareness, educate and drive conversation between people with Parkinson’s disease, their families and their doctors about how best to talk about and treat these non-motor symptoms.

“My father experienced hallucinations and delusions. At the time, we didn’t know any of these types of symptoms were part of his Parkinson’s disease,” Reynolds explains. “Like a lot of caregivers, my mom mostly tried to carry these burdens alone. I wish I’d known Parkinson’s disease wasn’t limited to only motor symptoms. I think people and families affected by Parkinson’s can be better prepared to manage hallucinations and delusions if they’re talking early and often about this lesser-known aspect of the disease.”

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/54103329/en.

“In my experience, most people living with Parkinson’s disease who experience hallucinations and delusions do not proactively tell their physicians about them unless specifically asked,” explains Dr. Yasar Torres-Yaghi, attending physician, director of Parkinsonism and Dementia Clinic at Georgetown University Hospital, Washington, D.C., a Parkinson’s Center of Excellence. “They may be frightened, embarrassed, or fear they are losing touch with reality. It’s important for people who are living with Parkinson’s and their loved ones to discuss all symptoms, motor and non-motor, with a doctor as there are treatment options available.”

More to Parkinson’s is an educational campaign, sponsored by Acadia Pharmaceuticals Inc., that aims to increase awareness among caregivers and patients of the existence of hallucinations and delusions as common parts of Parkinson’s disease. The campaign is anchored by a series of stories shared by Ryan and his mother, Tammy, as they relay their personal experiences from the perspective of a son and caregiver as well as a wife, mother, and caregiver, over the course of Jim’s disease. The multichannel campaign includes videos spanning a wide range of topics focusing on Parkinson’s-related hallucinations and delusions, covering who is at risk, what symptoms may look like, how to discuss symptoms and treatment options with a doctor, and more. The campaign will strive to reach the Parkinson’s disease community through digital media, social media and connected TV.

“There is a significant gap in awareness and understanding that hallucinations and delusions can be part of the progression of Parkinson’s disease,” said Steve Davis, Chief Executive Officer, Acadia. “As Ryan’s family story makes evident, the non-motor symptoms of Parkinson’s, including hallucinations and delusions, are often more distressing and disruptive than the motor symptoms associated with the disease. We are honored that Ryan and Tammy are willing to share their powerful story. Their experiences will open the door to desperately needed conversation and encourage people to speak with their healthcare providers about managing these symptoms.”

To learn more, visit MoretoParkinsons.com to find resources, including doctor and family discussion guides, and hear stories from people who have been affected by Parkinson’s-related hallucinations and delusions.

About Parkinson’s Disease and Parkinson’s-Related Hallucinations and Delusions

Parkinson’s disease is a progressive nervous system disorder that affects about one million people in the United States. 4,5 The signs and symptoms can vary with people experiencing both motor symptoms and non-motor symptoms such as hallucinations (seeing, hearing, or experiencing things that others don’t) and delusions (false beliefs). Physicians may refer to these Parkinson’s-related hallucinations and delusions as Parkinson’s disease psychosis. 3,6,8 Around 50 percent of people living with Parkinson’s disease may experience hallucinations or delusions during the course of their disease. 1 Non-motor symptoms, as a whole, can be more troublesome than motor symptoms, in terms of quality of life. 3 Parkinson’s disease psychosis may add to the burden of caring for a loved one with Parkinson’s disease. 9-11

About Acadia Pharmaceuticals Inc.

Acadia is advancing breakthroughs in neuroscience to elevate life. For 30 years we have been working at the forefront of healthcare to bring vital solutions to people who need them most. We developed and commercialized the treatment options for people living with hallucinations and delusions associated with Parkinson’s disease and Rett syndrome. Our clinical-stage development efforts are focused on treating, Prader-Willi syndrome, Alzheimer’s disease psychosis and multiple other programs targeting neuropsychiatric symptoms in central nervous system disorders. For more information, visit us at Acadia.com and follow us on LinkedIn and Twitter.

References

1 Forsaa EB, Larsen JP, Wentzel-Larsen T, et al. A 12-year population-based study of psychosis in Parkinson disease. Arch Neurol. 2010;67(8):996-1001.
2 Fénelon G, Mahieux F, Huon R, Ziégler M. Hallucinations in Parkinson’s disease: prevalence, phenomenology and risk factors .Brain. 2000;123(Pt 4):733-745.
3 Chaudhuri KR, Prieto-Jurcynska C, Naidu Y, et al. The nondeclaration of nonmotor symptoms of Parkinson’s disease to health care professionals: an international study using the nonmotor symptoms questionnaire. Mov Disord. 2010;25(6):704-709.
4 Parkinson’s Foundation. What is Parkinson’s? Retrieved from https://www.parkinson.org/Understanding-Parkinsons/Statistics. Accessed March 1, 2024.
5 Marras C, Beck JC, Bower JH, et al.; Parkinson’s Foundation P4 Group. Prevalence of Parkinson's disease across North America. NPJ Parkinsons Dis. 2018 Jul 10;4:21.
6 Ravina B, Marder K, Fernandez HH, et al. Diagnostic criteria for psychosis in Parkinson’s disease: report of an NINDS, NIMH work group. Mov Disord. 2007 Jun 15;22(8):1061-8.
7 Martinez-Martin P, Schapira AHV, et al. Prevalence of Nonmotor Symptoms in Parkinson’s Disease in an International Setting: Study using Nonmotor Symptoms Questionnaire in 545 Patients. Mov Disord. 2007; 22(11): 1623-1629.
8 Olanow CW, Schapira AHV. 2012. Parkinson’s Disease and Other Movement Disorders. Fauci AS (Ed), Harrison’s Principles of Internal Medicine (18th ed.).
9 Martinez-Martin P, Rodriguez-Blazquez C, et al. The Impact of Non-Motor Symptoms on Health Related Quality of Life of Patients with Parkinson’s Disease. Mov Disord. 2011;26(3):399-406.
10 Aarsland D, Bronnick K, Ehrt U, et al. Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry. 2007;78:36-42.
11 Schrag A, Hovris A, et al. Caregiver-burden in parkinson’s disease is closely associated with psychiatric symptoms, falls, and disability. Parkinsonism and Related Disorders. 2006;12:35-41.

Ryan & Tammy Reynolds (Photo: Business Wire)

Ryan & Tammy Reynolds (Photo: Business Wire)

BANGKOK (AP) — A new investigation focused on three of the world’s largest producers of shrimp released on Monday claims that as big Western supermarkets make windfall profits, their aggressive pursuit of ever-lower wholesale prices is causing misery for people at the bottom end of the supply chain.

The regional analysis of the industry in Vietnam, Indonesia and India, which provide about half the shrimp in the world’s top four markets — the United States, European Union, United Kingdom and Japan — is based on research done by an alliance of NGOs. It found a 20%-60% drop in earnings from pre-pandemic levels as producers struggle to meet pricing demands by cutting labor costs.

In many places this has meant unpaid and underpaid work through longer hours, wage insecurity as rates fluctuate, and many workers not even making low minimum wages.

Supermarkets linked to facilities where exploited labor was reported by workers include Target, Walmart and Costco in the United States, Britain’s Sainsbury’s and Tesco, and Aldi and Co-op in Europe.

The regional report brought together more than 500 interviews conducted in-person with workers in their native languages, in India, Indonesia and Vietnam — published separately as country-specific reports — supplemented with secondary data and interviews from Thailand, Bangladesh and Ecuador.

In Vietnam, Hawaii-based Sustainability Incubator investigators found that the workers who peel, gut and devein shrimp typically work six or seven days a week, often in rooms kept extremely cold to keep the product fresh.

Some 80% of those involved in processing shrimp are women, many of whom rise at 4 a.m. and return home at 6 p.m. Pregnant women and new mothers can stop one hour earlier, the report found.

In India, researchers from the Corporate Accountability Lab found that workers face “dangerous and abusive conditions.” Highly salinated water from newly dug hatcheries and ponds, tainted with chemicals and toxic algae, also contaminate surrounding water and soil.

Unpaid labor prevails, including salaries below minimum wage, unpaid overtime, wage deductions for costs of work and “significant” debt bondage, the report found. Child labor was also found, with girls aged 14 and 15 being recruited for peeling work.

In Indonesia, three non-profit research organizations found that wages have fallen since the COVID-19 pandemic and today average $160 per month for shrimp workers, below Indonesia’s minimum wage in most of the biggest shrimp-producing provinces. Shrimp peelers routinely are required to work at least 12 hours per day to meet minimum targets.

Switzerland’s Co-op said it had a “zero tolerance” policy for labor law violations and that its producers “receive fair and market-driven prices.”

Germany’s Aldi did not specifically address the issue of pricing, but said it uses independent certification schemes to ensure responsibly sourcing for farmed shrimp products, and would continue to monitor the allegations.

“We are committed to fulfilling our responsibility to respect human rights,” Aldi said.

Sainsbury’s referred to a comment from the British Retail Consortium industry group, which said its members were committed to sourcing products at a “fair, sustainable price” and that the welfare of people and communities in supply chains is fundamental to their purchasing practices.

The Vietnam Association of Seafood Exporters and Producers issued a statement calling the allegations in the report “unfounded, misleading and detrimental to the reputation of Vietnam’s shrimp exports,” citing government labor policies.

The NGO's report stresses that using middlemen to buy the shrimp obfuscates the true sources of shrimp that appear in western supermarkets, so many retailers may not be following ethical commitments they’ve made about procuring shrimp.

Only about 1,000 of the 2 million shrimp farms in the major producing countries are certified by either the Aquaculture Stewardship Council or the Best Aquaculture Practices ecolabel, making it "mathematically impossible for certified farms to produce enough shrimp per month to supply all of the supermarkets that boast commitments to purchasing certified shrimp,” the report says.

U.S. policymakers could use antitrust and other laws already in place to establish oversight to ensure fair pricing from western retailers, rather than imposing punishing tariffs on suppliers, says Katrin Nakamura of Sustainability Incubator, who wrote the regional report.

In July, the European Union adopted a new directive requiring companies to “identify and address adverse human rights and environmental impacts of their actions inside and outside Europe.”

Officials from Indonesia and Vietnam have met with the report's authors to discuss their findings and look for solutions.

Given the current disparity in retail and wholesale prices, paying more to farmers would not have to mean higher prices for consumers, the Sustainability Incubator report said, but it would mean lower profits for the supermarkets.

“Labor exploitation in shrimp aquaculture industries is not company, sector, or country-specific,” the report concludes. “Instead, it is the result of a hidden business model that exploits people for profit.”

This story was supported by funding from the Walton Family Foundation. The AP is solely responsible for all content.

Yulius Cahyonugroho poses for a photo at his shrimp farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Yulius Cahyonugroho poses for a photo at his shrimp farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Workers sort shrimps at a farm in Kebumen, Centra Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Workers sort shrimps at a farm in Kebumen, Centra Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Farm worker Dias Yudho Prihantoro, left, harvests shrimps at a farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Farm worker Dias Yudho Prihantoro, left, harvests shrimps at a farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Farm worker Andika Yudha Agusta feed shrimps at a shrimp farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Farm worker Andika Yudha Agusta feed shrimps at a shrimp farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Workers harvest shrimps at a farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

Workers harvest shrimps at a farm in Kebumen, Central Java, Indonesia, Tuesday, Sept. 24, 2024. (AP Photo/Dita Alangkara)

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