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Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

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Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment
Business

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Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

2024-09-16 19:00 Last Updated At:19:15

NANJING, China, Sept. 16, 2024 /PRNewswire/ -- Vazyme (688105.SH), a leading life science technology company, significantly contributed to groundbreaking research published in Science Magazine through its innovative products. The study, which focuses on how mutant IDH1 inhibition activates tumor immunity by inducing double-stranded DNA (dsDNA) sensing, utilized Vazyme's advanced tools to achieve compelling research results. These findings are driving progress in life science, fostering transformative changes and innovations, and advancing both academic research and the broader medical sector.

The research, led by the cancer research team at Harvard Medical School and Massachusetts General Hospital and the Broad Institute of MIT and Harvard, was authored by Dr. Meng-Ju Wu and his team. Reporting in Science, their paper, "Mutant IDH1 Inhibition Induces dsDNA Sensing to Activate Tumor Immunity", reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Research has found that mIDH1 inhibitors cause DNA demethylation, which reactivates dormant viral genes embedded in the genome from ancient infections, subsequently activating cGAS, a protein responsible for detecting these viral elements. This reactivation triggers a viral mimicry response, effectively mobilizing the immune system to attack and destroy tumor cells. In preclinical models, mIDH1 inhibition led to the rapid recruitment of CD8+ T cells and a strong anti-tumor immune response. These findings suggest that strategies enhancing viral mimicry and immune activation could significantly boost the efficacy of mIDH1 inhibitors, paving the way for innovative combination therapies to combat mIDH1-driven cancers.

Three products from Vazyme were instrumental in this significant research: Equalbit 1 × dsDNA HS Assay Kit (#EQ121), Mycolor One-Step Mycoplasma Detector (#D201), and BCA Protein Quantification Kit (#E112). Among them, Vazyme #EQ121 is a ready-to-use double-stranded DNA (dsDNA) quantification kit that is easy to use, highly sensitive, and accurately quantifies 0.2 - 100 ng dsDNA. By utilizing the dye that specifically binds to DNA and reducing interference from impurities, along with strict standard controls, it provides a good linear relationship in the 0.2 - 100 ng range, achieving accurate quantification. It is an ideal choice for large-scale DNA sample quantification in NGS (e.g., input DNA quantification, DNA library quantification).

Additionally, Vazyme has launched an upgraded mycoplasma detection reagent--the Mycolor One-Step Mycoplasma Detector (#D201). The product introduces a novel red-yellow color change system, which makes operation easy and visually intuitive. Reliable cell culture is vital for cell research; however, mycoplasma contamination remains a frequent and challenging issue. Unlike yeast and bacteria, mycoplasma cannot be directly observed under a microscope, which makes detection more complex. By using isothermal amplification technology to detect whether cells are contaminated with mycoplasma through color change, it provides great convenience for researchers.

The BCA Protein Quantification Kit (#E112) is one of the most sensitive methods for measuring protein concentration. Boasting unparalleled versatility across diverse experimental settings, it enables the exploration of standard curve linearity while maintaining the ease of operation.

These exceptional products, from Cell and Protein Research product line to NGS Library Preparation product line, directly result from Vazyme's strong research and development capabilities, which form the foundation of its innovations. The dedicated R&D team has developed over 600 types of genetically engineered recombinant enzymes, more than 2,500 high-performance antigens, monoclonal antibodies, and other essential materials. Driven by the robust enzyme library and following a logical progression in disease management—from discovery and prevention to diagnosis and treatment, Vazyme has established nine major product lines along with over 2,000 end products: Nucleic Acid Extraction Reagents, Molecular Biology Reagents, Cell & Protein Research Reagents, NGS Library Preparation Reagents, Reagents for Bio-Medicine, Instruments, Lab Consumables, Animal Disease Detection Kits, and IVD Solutions.

Vazyme prioritizes global customer connections, ensuring their satisfaction. Through local customer support teams in key markets, the company engages directly with users in over 60 countries with local warehouses for efficient delivery and service.

By leveraging technical expertise in various disciplines, including enzymology, immunology, cell biology, material science, and organic chemistry, Vazyme solidifies its role as a vital partner in scientific exploration. The driving force behind Vazyme's work is empowering customers in their pursuit of advancing the innovation of science. And together, exploring the unknown and fostering collaborations towards a healthier life for all.

For more information, please visit the following website:
www.vazyme.com 

E-mail: support@vazyme.com
Tel: +86 400-168-5000

** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **

Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

What truly differentiates VinCSS is its ability to enable organizations, OEM manufacturers, and service providers to adopt FDO standards without investing in building their own infrastructure from scratch.

SAN ANTONIO, Jan. 23, 2025 /PRNewswire/ -- Frost & Sullivan recently assessed the internet of things (IoT) security industry and based on its analysis results, recognizes VinCSS with the 2024 Global Transformational Innovation Leadership Award. The company has emerged as a cybersecurity trailblazer in passwordless authentication technology using FIDO2 (Fast IDentity Online 2) standards and is a pioneer in FIDO device onboarding (FDO) adoption for IoT device security.

VinCSS has positioned itself as a pioneer in the IoT security industry through its commitment to innovation, standardization, and strategic partnerships. It became the world's first company to introduce a commercial IoT security platform and ecosystem designed to simplify IoT onboarding and ensure secure device management using the FDO standards. By adopting the FDO standards, VinCSS addresses critical security vulnerabilities and the growing risk of cyberattacks with a unified, automated solution that enhances security across IoT deployments. The company has further solidified its leadership by becoming the first in the industry to achieve three FDO certifications from the FIDO Alliance. FDO technology is transforming the IoT landscape by automating device onboarding, significantly reducing time and effort, particularly when it concerns thousands of devices. This innovation replaces labor-intensive, manual processes prone to human error and high costs, making FDO a game changer for secure and efficient IoT management.

VinCSS's FDO solutions minimize the risks of mistakes and security vulnerabilities to ensure consistent, secure onboarding. Its automated FDO protocol cuts onboarding time by up to 90%, enabling organizations to save time, effort, and costs in deploying devices. It also enhances the reliability and security of the onboarding process by eliminating human involvement and freeing IT teams to focus on more strategic initiatives rather than being bogged down by repetitive, manual tasks. The FDO protocol leverages advanced authentication standards that allow devices to be securely onboarded with minimal manual intervention, making it a viable approach for large-scale deployments, such as smart cities or industrial IoT environments, where managing thousands of devices can quickly become unmanageable and error-prone without automation. In addition, VinCSS's FDO solution integrates seamlessly with organizations' existing security ecosystems using a zero-touch onboarding approach that enables the addition of existing devices to a network without direct human involvement, which is crucial in scenarios where scalability and stability are vital, such as manufacturing plants, smart healthcare systems, or expansive sensor networks in smart cities.

Anh Tien Vu, Industry Principal, Global Cybersecurity Practice, Frost & Sullivan, observed, "VinCSS delivers game-changing IoT security solutions that address current challenges and set new benchmarks for the future. It is one of the first companies to commercialize products and services integrated with FDO standards. While many organizations are still exploring the potential of FDO since its introduction by the FIDO Alliance in 2021, VinCSS has taken decisive steps to implement this technology in real-world scenarios."

VinCSS has gone beyond merely adopting the FDO protocols by building a comprehensive, turnkey FDO infrastructure and setting a benchmark in the IoT security industry with the Device Onboarding Services, FDO-enabled devices, and the Rendezvous Server. Unlike market players that only provide fragmented products, VinCSS's comprehensive ecosystem offers an end-to-end onboarding ecosystem that allows seamless integration for IoT deployments. With VinCSS's comprehensive solutions, organizations can quickly achieve FDO compliance, facilitating device enrollment. By providing this capability, VinCSS positions itself as a provider of IoT security solutions and a key partner for hardware manufacturers and service providers looking to adopt FDO standards while maintaining high security and overcoming the barriers of cost and complexity for a faster time to market. Infrastructure development is a significant achievement as it helps lower the barrier to entry for IoT security, which encourages wider adoption of secure onboarding protocols across various industries. VinCSS's leadership in building a scalable, FDO-certified infrastructure has made it a catalyst for industry transformation and provides other vendors with the tools they need to secure their devices more effectively. By launching multiple FDO-enabled solutions, including integrated cameras, Wi-Fi routers, smart car parking sensors and network deployment solutions, VinCSS has gained a competitive edge as a first mover to gain traction across multiple sectors, including smart cities, healthcare, manufacturing, and automotive. VinCSS is a market leader with its unique and comprehensive product ecosystem, innovative approach, and robust industry partnerships.

"VinCSS is not only responding to current industry needs but also proactively shaping the future of IoT security through its early adoption and practical application of FDO technology, by providing automated, secure onboarding solutions and actively leading standardization efforts. With the likelihood of FDO becoming widely adopted or mandatory in specific industries, much like the FIDO2 standard and passkey today, VinCSS is well positioned to lead industry transformation moving forward," added Vu.

With its strong overall performance, VinCSS earns Frost & Sullivan's 2024 Global Transformational Innovation Leadership Award in the IoT security industry. It is also the third consecutive time VinCSS has been awarded by Frost & Sullivan.

Each year, Frost & Sullivan presents this award to the company that has developed a product with innovative features and functionality that is gaining rapid acceptance in the market. The award recognizes the quality of the solution and the customer value enhancements it enables.

Frost & Sullivan Best Practices awards recognize companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry.

About Frost & Sullivan

For six decades, Frost & Sullivan has been world-renowned for its role in helping investors, corporate leaders, and governments navigate economic changes and identify disruptive technologies, megatrends, new business models, and companies to action, resulting in a continuous flow of growth opportunities to drive future success. Contact us: Start the discussion. Contact us: Start the discussion.

Contact:

Tarini Singh
E: tarini.singh@frost.com

** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **

VinCSS Applauded by Frost & Sullivan for its Pioneering FIDO IoT Device Onboarding (FDO) Security and its Transformational Innovation Leadership

VinCSS Applauded by Frost & Sullivan for its Pioneering FIDO IoT Device Onboarding (FDO) Security and its Transformational Innovation Leadership

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