MONTERREY, Mexico, Sept. 18, 2024 /PRNewswire/ -- Hoymiles, a world-leading provider of PV & energy storage solutions, officially inaugurated its first overseas manufacturing facility in Monterrey, Mexico, marking a significant milestone in the company's global expansion strategy.
Located in the Vynmsa Industrial Park, just 6 kilometers from the airport, the 6,700-square-meter facility is equipped with comprehensive production resources, including dedicated PCBA, materials, and finished goods warehouses. With a current workforce of 170 employees, the facility is designed to maximize both production efficiency and quality.
The factory will focus on producing microinverters, such as the HMS-2000-4T and HMS-2000DW-4T series, for both residential and commercial solar applications. With an initial annual production capacity of 500,000 units, the facility is set for future expansion, aiming to double its output with additional production lines. This expansion will help Hoymiles better address the growing renewable energy needs of the region.
The opening of this facility represents more than just an increase in manufacturing capabilities; it reflects Hoymiles' strategic vision for localized production. By being closer to key markets, Hoymiles will improve service responsiveness, reduce delivery times, and offer more competitive pricing while ensuring high-performance products that meet local demands.
Hoymiles CEO Dr.Yang Bo remarked, "The Monterrey facility is a significant milestone and demonstrates our commitment to supporting renewable energy transitions in North and Latin America. This factory will be crucial in meeting the region's growing needs for solar and energy storage solutions."
Guy Rong, Vice President of Hoymiles added, "This new facility marks a new chapter for Hoymiles, enabling us to provide better services for the local market and position ourselves as a key player in the renewable energy landscape."
The Monterrey facility is significant for enhancing Hoymiles' service capabilities in the Americas and aligns with its dedication to adapting to industry changes and market demands. The facility will streamline operations, improve service efficiency, and reinforce Hoymiles' commitment of "Open Energy for All".
About Hoymiles
Founded in 2012, Hoymiles is a clean energy solution provider, specializing in module-level inverters and storage systems. With a vision of a clean, sustainable future, the company strives to drive innovation in the smart energy industry with its high-performance, accessible products. For more information, please visit www.hoymiles.com.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Hoymiles Inaugurates Mexico Manufacturing Facility, Strengthening Support for North and Latin America
Hoymiles Inaugurates Mexico Manufacturing Facility, Strengthening Support for North and Latin America
SHANGHAI, Sept. 19, 2024 /PRNewswire/ -- Abbisko Therapeutics (HKEX: 02256) is excited to announce the receipt of the ESMO 2024 Best Poster Award on September 16, 2024. The award was received for the presentation titled "Updated Safety and Efficacy of Irpagratinib (ABSK011) in advanced hepatocellular carcinoma (aHCC) with FGF19 overexpression from a Phase 1 study". The update data from ABSK-011-101 study showed a tolerable safety profile and promising anti-tumor activity of Irpagratinib monotherapy in aHCC. Of note, in aHCC patients who were pretreated with both immune checkpoint inhibitor (ICI) and Tyrosine Kinase Inhibitor (TKI)—a population with high unmet need in the current treatment paradigm—the observed ORR and DCR was 44.8% and 79.3%, respectively, with a median duration of response (mDoR) of 7.4 months and median progression free survival (mPFS) of 5.5 months.
The poster, #983P, was presented at the Hepatocellular Carcinoma poster session on Sunday, September 16, 2024. The Best Poster Award was given at the conclusion of the Sunday Poster Session, with only one recipient being honored in HCC poster session.
As of September 5, 2024, 122 patients have been enrolled, including 74 in the BID cohort with doses consisting of 160mg BID, 220mg BID, and 300mg BID. 5.4% of patients were BCLC Stage B, and 89.2% BCLC Stage C, 64.9% had a Child-Pugh (CP) Score of 5, 27% CP Score of 6, and 6.8% CP Score of 7. 64.9% of patients received multiple lines of prior therapy, 85.1% of patients had previously been treated with ICIs, and 75.7% of patients had previously been treated with both ICIs and mTKIs.
The efficacy data show that forty pre-treated HCC patients with FGF19 overexpression were treated with irpagratinib 220 mg BID. Among the 38 evaluable patients, the response rate was 36.8% (14/38), and the disease control rate (DCR) was 78.9% (30/38). The response rate from the subset of patients who had previously received ICI and mTKI therapy was 44.8% (13/29). The longest observed DoR was 16.4 months and the mDoR was 7.4 months. DCR was 79.3% (23/29). mPFS was 5.5 months.
Safety data show one dose-limiting toxicity (DLT) was observed in the 300 mg BID cohort. The most common treatment-related adverse effects (TRAEs, >20%) were ALT elevation, diarrhea, AST elevation, hyperphosphatemia, bilirubin elevation, alkaline phosphatase elevation, platelet decrease, and total bile acid elevation. Grade 3-4 treatment-related adverse events (>5%) included AST elevation, ALT elevation, and diarrhea. No grade 5 adverse events occurred.
HCC is the main type of liver cancer, accounting for 85% to 90% of primary liver cancers. HCC is highly malignant, about 30% of which have abnormally high FGFR4 expression and a poor prognosis, and the existing treatment methods still cannot meet the long-term survival benefits. Currently, there is no approved standard of care for HCC patients who have progressed from first-line ICI-based therapies. The FGF19/FGFR4 signaling axis could be a novel therapeutic target for HCC. ABSK-011, a potent FGFR4 inhibitor, demonstrated a tolerable safety profile and promising anti-tumor activity as a single agent. Notably, the irpagratinib 220mg BID regimen exhibited a 44.8% ORR, 7.4 months mDoR and 5.5 months mPFS in heavily pre-treated HCC patients who had received both ICI and mTKI therapy, supporting further late-stage development of irpagratinib in such populations with substantial unmet medical need.
In addition, the design of the phase II study of pimicotinib in combination with chemotherapy and with/without toripalimab as first-line treatment for advanced pancreatic ductal adenocarcinoma (PDAC) has been presented.
About Irpagratinib (ABSK011)
Irpagratinib is a highly selective FGFR4 small molecule inhibitor intended for the treatment of advanced solid tumors that present with abnormalities in the FGF19/FGFR4 signaling pathway (e.g., ligand FGF19 amplification/overexpression, FGFR4 mutation/amplification/fusion), including advanced HCC, cholangiocarcinoma, breast cancer, among others. The FGFR4 signaling pathway is a recognized and promising target for treating HCC. Clinical data with irpagratinib have demonstrated improved potency and anti-tumor efficacy, among other favorable therapeutic properties, compared to competitors.
About Abbisko Therapeutics
Founded in April 2016, Abbisko Therapeutics Co., Ltd., a subsidiary of Abbisko Cayman Limited (Stock Code on the Hong Kong Stock Exchange: 2256.HK), is an oncology-focused biopharmaceutical company founded in Shanghai, dedicated to the discovery and development of innovative medicines that treat unmet medical needs in China and globally. The Company was established by a group of seasoned drug hunters with rich R&D and managerial expertise from top multinational pharmaceutical companies. Since its founding, Abbisko Therapeutics has built an extensive pipeline of 16 innovative small molecule programs focused on precision oncology and immuno-oncology. Please visit www.abbisko.com for more information.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Best Poster of ESMO 2024! Abbisko Announces Updated Clinical Data of Irpagratinib in HCC
