SEOUL, South Korea and PROVIDENCE, R.I., Sept. 18, 2024 /PRNewswire/ -- Hyundai Motor Group and Rhode Island School of Design (RISD) announce the launch of the Regeneration Studio, the latest phase of work in an ambitious multiyear research partnership exploring the relationship between nature, art and design, and the future of mobility.
Now in its fifth year, the 2024–25 collaboration brings together RISD faculty members and student researchers with Hyundai Motor, Genesis and Kia designers to design around the theme of Future Structures.
The Regeneration Studio, led by an advanced scientific team in RISD's Edna W. Lawrence Nature Lab, aims to develop entirely new concepts for bio-innovation. This year's programming comprises a fall biomimicry seminar, spring studio courses and extended research into the summer.
"RISD's ongoing collaboration with Hyundai Motor Group reflects our shared commitment to fostering a sustainable society and amplifying the expertise and creativity of students, faculty and staff," said RISD President Crystal Williams. "RISD and Hyundai Motor Group are conceiving of future realities that change the way we move through space, understand and use materials, and interpret structures in support of a flourishing and healthy ecological system. We are thrilled to continue investigating the future of mobility with our partners at Hyundai Motor Group, and thank them for their continued investment in this endeavor."
"The Regeneration Studio fosters innovation by integrating nature's design principles with advanced studio practices, aiming to restore the relationship between humanity and living systems," said SangYup Lee, Head of Hyundai & Genesis Global Design. "Through the Regeneration Studio, this partnership not only advances sustainable design solutions but also lays the foundation for a long-term Sustainable Research Initiative, driving future innovation in mobility and beyond."
"RISD is guided by deep inquiries, generating actionable results that respect principles of design and the world in which they intervene. This mutually respectful dialogue allows us to find answers to industry needs through the study of nature as a generous, inventive, and boundless source of knowledge," said RISD Provost Touba Ghadessi. "Scientists, designers, makers, and visionary colleagues at Hyundai Motor Group and at RISD research biomimicry, regenerative practices, and artificial intelligence to conceive of humans and the planet as an integrated system. In doing so, this ambitious partnership sees the future of mobility as a new paradigm where pragmatic approaches, environmental justice, and creative practice work in harmony."
"Nature doesn't just inspire — it challenges us to rethink and regenerate," said Karim Habib, Head of Kia Global Design. "By learning from nature's resilience, we're discovering new ways to reimagine and shaping a future where human wellness and the planet not only coexist in balance but also move forward together."
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Hyundai Motor Group and Rhode Island School of Design Expand Partnership with Launch of New Regeneration Studio
SHANGHAI, Sept. 19, 2024 /PRNewswire/ -- Abbisko Therapeutics (HKEX: 02256) is excited to announce the receipt of the ESMO 2024 Best Poster Award on September 16, 2024. The award was received for the presentation titled "Updated Safety and Efficacy of Irpagratinib (ABSK011) in advanced hepatocellular carcinoma (aHCC) with FGF19 overexpression from a Phase 1 study". The update data from ABSK-011-101 study showed a tolerable safety profile and promising anti-tumor activity of Irpagratinib monotherapy in aHCC. Of note, in aHCC patients who were pretreated with both immune checkpoint inhibitor (ICI) and Tyrosine Kinase Inhibitor (TKI)—a population with high unmet need in the current treatment paradigm—the observed ORR and DCR was 44.8% and 79.3%, respectively, with a median duration of response (mDoR) of 7.4 months and median progression free survival (mPFS) of 5.5 months.
The poster, #983P, was presented at the Hepatocellular Carcinoma poster session on Sunday, September 16, 2024. The Best Poster Award was given at the conclusion of the Sunday Poster Session, with only one recipient being honored in HCC poster session.
As of September 5, 2024, 122 patients have been enrolled, including 74 in the BID cohort with doses consisting of 160mg BID, 220mg BID, and 300mg BID. 5.4% of patients were BCLC Stage B, and 89.2% BCLC Stage C, 64.9% had a Child-Pugh (CP) Score of 5, 27% CP Score of 6, and 6.8% CP Score of 7. 64.9% of patients received multiple lines of prior therapy, 85.1% of patients had previously been treated with ICIs, and 75.7% of patients had previously been treated with both ICIs and mTKIs.
The efficacy data show that forty pre-treated HCC patients with FGF19 overexpression were treated with irpagratinib 220 mg BID. Among the 38 evaluable patients, the response rate was 36.8% (14/38), and the disease control rate (DCR) was 78.9% (30/38). The response rate from the subset of patients who had previously received ICI and mTKI therapy was 44.8% (13/29). The longest observed DoR was 16.4 months and the mDoR was 7.4 months. DCR was 79.3% (23/29). mPFS was 5.5 months.
Safety data show one dose-limiting toxicity (DLT) was observed in the 300 mg BID cohort. The most common treatment-related adverse effects (TRAEs, >20%) were ALT elevation, diarrhea, AST elevation, hyperphosphatemia, bilirubin elevation, alkaline phosphatase elevation, platelet decrease, and total bile acid elevation. Grade 3-4 treatment-related adverse events (>5%) included AST elevation, ALT elevation, and diarrhea. No grade 5 adverse events occurred.
HCC is the main type of liver cancer, accounting for 85% to 90% of primary liver cancers. HCC is highly malignant, about 30% of which have abnormally high FGFR4 expression and a poor prognosis, and the existing treatment methods still cannot meet the long-term survival benefits. Currently, there is no approved standard of care for HCC patients who have progressed from first-line ICI-based therapies. The FGF19/FGFR4 signaling axis could be a novel therapeutic target for HCC. ABSK-011, a potent FGFR4 inhibitor, demonstrated a tolerable safety profile and promising anti-tumor activity as a single agent. Notably, the irpagratinib 220mg BID regimen exhibited a 44.8% ORR, 7.4 months mDoR and 5.5 months mPFS in heavily pre-treated HCC patients who had received both ICI and mTKI therapy, supporting further late-stage development of irpagratinib in such populations with substantial unmet medical need.
In addition, the design of the phase II study of pimicotinib in combination with chemotherapy and with/without toripalimab as first-line treatment for advanced pancreatic ductal adenocarcinoma (PDAC) has been presented.
About Irpagratinib (ABSK011)
Irpagratinib is a highly selective FGFR4 small molecule inhibitor intended for the treatment of advanced solid tumors that present with abnormalities in the FGF19/FGFR4 signaling pathway (e.g., ligand FGF19 amplification/overexpression, FGFR4 mutation/amplification/fusion), including advanced HCC, cholangiocarcinoma, breast cancer, among others. The FGFR4 signaling pathway is a recognized and promising target for treating HCC. Clinical data with irpagratinib have demonstrated improved potency and anti-tumor efficacy, among other favorable therapeutic properties, compared to competitors.
About Abbisko Therapeutics
Founded in April 2016, Abbisko Therapeutics Co., Ltd., a subsidiary of Abbisko Cayman Limited (Stock Code on the Hong Kong Stock Exchange: 2256.HK), is an oncology-focused biopharmaceutical company founded in Shanghai, dedicated to the discovery and development of innovative medicines that treat unmet medical needs in China and globally. The Company was established by a group of seasoned drug hunters with rich R&D and managerial expertise from top multinational pharmaceutical companies. Since its founding, Abbisko Therapeutics has built an extensive pipeline of 16 innovative small molecule programs focused on precision oncology and immuno-oncology. Please visit www.abbisko.com for more information.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Best Poster of ESMO 2024! Abbisko Announces Updated Clinical Data of Irpagratinib in HCC
