PeptiGrowth Inc. is Launching a Novel Synthetic FGF2 Alternative Peptide (FGFR1c Agonist)

TOKYO, Oct. 1, 2024 /PRNewswire/ -- PeptiGrowth Inc. (Headquarters: Chiyoda-ku, Tokyo; President: Jiro Sugimoto) has successfully developed a novel synthetic peptide called "FGF2 alternative peptide (FGFR1c agonist)", which has equivalent function to recombinant FGF2 (Fibroblast Growth Factor 2, basic FGF (bFGF)). This product will be on the market at the beginning of October 2024.

Development of Synthetic Peptide Growth Factors by PeptiGrowth

Traditional growth factors and cytokines used in regenerative medicine and cell therapy manufacturing face several quality issues, including lot-to-lot variability, potential contamination with biological impurities, low stability, and high costs. PeptiGrowth has focused on developing a series of synthetic peptides that address these challenges while maintaining functionality equivalent to conventional growth factors and cytokines. Their peptides are completely chemically synthesized and free from animal components, enabling the formulation of xeno-free and chemically defined cell culture media.

About FGF2 alternative peptide (FGFR1c agonist) [Product code: PG-011]

The FGF2 Alternative Peptide (PG-011) is a dimeric peptide composed of cyclic peptides that bind to human FGFR1c. PG-011 exhibits agonist activity toward FGFR1c by binding to it, thereby activating signaling pathways in various cell types.

PeptiGrowth has confirmed that PG-011 promotes the proliferation of human mesenchymal stem cells (MSCs) at approximately one-third the concentration of FGF2 when compared on a ng/mL basis. Additionally, in collaboration with the CiRA Foundation, they evaluated PG-011's ability to maintain the undifferentiated state of human iPSCs. Three iPSC lines were cultured for 7 days in media containing either 100 ng/mL (~5.9 nM) of FGF2 or the same molar concentration (equivalent to ~30 ng/mL) of PG-011, followed by three passages. Afterward, cell morphology observations and undifferentiated marker measurements were conducted. Following three passages, iPSCs cultured in both PG-011 and FGF2 exhibited nearly identical morphology. Furthermore, analysis of undifferentiated markers (SSEA4 and TRA-1-60) indicated that iPSCs cultured with PG-011 displayed a similar positivity rate to those cultured with FGF2. Cell proliferation rates during the culture period were also equivalent under both conditions. These results suggest that PG-011 has the ability to maintain iPSCs in an undifferentiated state, comparable to FGF2.

Recombinant FGF2 is known for its low stability, as it degrades and loses activity easily under culture conditions. This necessitates higher concentrations and frequent medium changes, significantly increasing production costs and workload. PeptiGrowth has confirmed that PG-011 maintained its full activity even after 4 days of incubation at 37°C, whereas FGF2's activity significantly declined under the same conditions, demonstrating the superior stability of PG-011.

Moreover, they assessed the reactivity of PG-011 with bovine cells, as FGF2 is a key growth factor in cultivated meat production. PG-011 efficiently promoted the proliferation of bovine muscle satellite cells, suggesting that PG-011 may demonstrate cross-reactivity across various cell types, including those of non-human origin, making it a promising candidate for use in cultivated meat production.

PG-011 provides cell proliferation and undifferentiated state maintenance comparable to FGF2 but with superior stability, reducing both usage costs and workload. It also shows excellent proliferation activity in both human and bovine cells, making it a compelling choice for regenerative medicine and cultivated meat production.

Product name:                  FGF2 alternative peptide (FGFR1c agonist)
Product code:                   PG-011
Product form:                   Lyophilized
Storage conditions:           -20°C or less
Purity:                              ≥95% by HPLC
Molecular weight:             5127.81(Acetate)
Size:                                 10 µg, 50 μg (volume per glass vial)

*This product can be provided with an Animal Component Free (ACF) certificate.
*This product is for testing and research use only (RUO).
*There is a possibility that the specifications can change.

If you would like to purchase our products, please contact us using the information below.

For customers who would like to purchase GMP compliant products as well as the above PG products in bulk scale, please contact us using the information below.

Development of other peptides from PeptiGrowth

We have developed alternative peptides targeting numerous growth factors and cytokines. To date, we have launched 11 products and plan to launch several additional growth factor alternative peptides targeting PDGF-AA, KGF, and IL-15 between late 2024 and mid- 2025. Details will be updated on our website (https://peptigrowth.com/en/) . If you are interested, please contact us using the following contact information.

Contacts for inquiries or additional information:

PeptiGrowth Inc.               E-mail: contact@peptigrowth.com     TEL：+81-70-4503-1497

** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **

PeptiGrowth Inc. is Launching a Novel Synthetic FGF2 Alternative Peptide (FGFR1c Agonist)

PeptiGrowth Inc. is Launching a Novel Synthetic FGF2 Alternative Peptide (FGFR1c Agonist)

SUZHOU, China , Oct. 1, 2024 /PRNewswire/ -- The 144-hour visa-free transit allows travelers to cross mountains and seas to pursue love, but it is not enough to explore the deep history and heartfelt stories of a city.

With the recovery of global tourism and the further opening of China's tourism market, Suzhou, a popular tourist destination in Jiangsu province in East China, has proven itself to be a burgeoning international tourism hub thanks to the "144-hour visa-free transit and group travel visa-free policy." In the first seven months of this year, Suzhou received a total of 495,000 overnight tourists, marking a year-on-year increase of 97.9%.

The slogan "Go to China, and travel in Suzhou," serves as a sincere invitation from Suzhou Cultural Tourism to the world. While "China Travel" goes viral on the Internet, how can "Suzhou Travel" remain low profile?

From September 25 to 26, a massive poster showcasing an oriental garden occupied screens in the core business districts of London, United Kingdom, and Auckland, New Zealand, revealing the picturesque scenery of Suzhou. The watercolor-like image drew the attention of countless passersby, prompting questions about Suzhou's location in such a vast country and aspirations to visit.

As soon as foreign tourists set foot in Suzhou, they will discover surprises everywhere.

Zina, a beauty Vlogger from the Czech Republic with nearly six million followers, recorded a Vlog capturing her 24-hour experience in Suzhou. Dressed in a silk cheongsam, she boarded a boat to listen to the Jiangnan ditty sung by the boatman in a gentle dialect and walked along the historic Pingjiang Road to soak in the "slow time" of old Suzhou.

In contrast to Zina, Jason, a British Vlogger with one million followers, dedicated most of his "24 hours in Suzhou" to experiencing the allure of "oriental opera." He visited the China Kunqu Opera Museum and the Suzhou Pingtan Museum, enjoying classics like "The Peony Pavilion" along with famous Pingtan selections including "Good Scenery of Suzhou." After "rewarding" his ears with local music, Jason further indulged his taste buds with a wide variety of Suzhou-style dishes and exquisite pastries that left him craving more.

Jared, a Canadian Vlogger with a million followers, only has eyes for Suzhou's classical gardens and picturesque water towns. He loudly greeted passers-by while jogging on the Wuque Bridge in the morning. Then, he enjoyed a hearty morning tea in a 30-year-old tea house. After a bowl of Gorgon fruit (known as "ginseng in water") syrup, Jared became even more determined to stay in Suzhou. Dressed in Han-style clothing, Jared joined the "travel photography" crowd and asked a photographer to take photos of him. Quickly, the blond blended into the ancient buildings of Suzhou without any sense of incongruity.

Similar to them, many foreign Vloggers have recorded their wonderful experiences in Suzhou in different ways. Their followers, attracted by their recommendations, said they really wanted to come to Suzhou and have a wonderful experience.

In order to live up to the expectations and love of foreign tourists for Suzhou, Suzhou Cultural Tourism has shown its full sincerity.

In May this year, the Suzhou Municipal People's Government issued the "Several Measures to Promote Suzhou Inbound Tourism (Trial)." This three-chapter policy contains ten incentives, creating a convenient and friendly environment for overseas tourists in every aspect upon their landing in China.

A thousand words are not worth a sincere meeting. It is a big world. China is a beautiful country. Suzhou is a gorgeous place. Just come. Suzhou welcomes you.

** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **

Suzhou: A City Worthy of More Than a 144-Hour Stay