BILLERICA, Mass.--(BUSINESS WIRE)--Nov 8, 2024--
Bruker Corporation (Nasdaq: BRKR) today announced a major technological breakthrough in the CellScape™ Precise Spatial Proteomics platform for highly multiplexed immunofluorescence (IF). Launched in 2022, the CellScape platform has advanced the field of spatial proteomics with differentiated quantitative performance enabled by a unique combination of best-in-class resolution and high dynamic range (HDR) imaging. CellScape captures the entire continuum of protein expression in a biological sample—from least to most abundant—while capturing fine morphological details. CellScape utilizes directly-labeled primary antibodies, enabling a robust and modular chemistry that allows researchers to build assays by combining panels and/or individual markers, even after the conclusion of an experimental run. With this new technology, Bruker has further advanced the CellScape chemistry with EpicIF (Enhanced photobleaching in cyclic immunofluorescence), which expands the range of compatible commercially available fluorophore conjugated antibodies by nearly 10-fold, simplifies assay development, and increases throughput by up to 2-fold. EpicIF enhances photobleaching efficacy combining a proprietary reagent with visible light to gently erase fluorescence signal from nearly any fluorophore and, like the prior version, the epitopes are preserved while maintaining tissue integrity.
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EpicIF is supported by the concurrent release of a new version of the software. The new software, CellScape™ Navigator, also introduces a more intuitive user interface and easy experiment setup. Both EpicIF and CellScape Navigator will be available as upgrades to current CellScape instruments. “This breakthrough gives scientists an unmatched level of flexibility in their highly multiplexed IF experiments,” said Ranga Partha, PhD, Senior Vice President of Product Management and Marketing at Bruker Spatial Biology. “This new advancement builds on the best-in-class performance of the CellScape, which already offers differentiated quantitative performance, reliability, and modularity at any time. Now, by enabling the erasure of previously photostable fluorophore signals, researchers can choose a wider selection of antibody conjugates than ever before. In addition, EpicIF enables compatibility of the CellScape platform with additional fluorescent readouts, such as RNA-ISH. It’s a leap forward in versatility for high-throughput spatial proteomics and we’re thrilled to offer this transformative technology to our customers.”
Oliver Braubach, PhD, Director of R&D Assays at Bruker Spatial Biology, added, “We have developed a solution that overcomes the limitations of traditional multiplexing. The ability to erase signal from a wide range of organic fluorescent dyes without damaging tissues not only simplifies workflows, but also allows scientists to use antibodies validated in other workflows, providing cost and time savings on assay optimization. The use of directly-labeled primary antibodies also eliminates the cross-reactivity observed in other spatial proteomic techniques that rely on secondary antibodies." Bruker Spatial Biology will be sharing more about this new advancement at the Society for Immunotherapy of Cancer (SITC) 2024 Annual Meeting from Nov 8-10 in Houston, Texas at booth #419. For additional information, visit www.brukerspatialbiology.com/EpicIF.
About Bruker Spatial Biology
Bruker Spatial Biology, a division of Bruker Corporation, provides advanced spatial solutions, including instruments, assays, software, and services to support life sciences research from discovery to translation. Best-in-class technologies include the CosMx® SMI with data analysis by the AtoMx™ SIP, GeoMx® DSP, CellScape™ platform, and nCounter® system. Canopy Multiomic Services provides access to these technologies for biopharmaceutical research, custom assay development, and clinical sample testing. Learn more at www.brukerspatialbiology.com.
About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR)
Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit www.bruker.com.
Human FFPE tonsil, 48-plex proteomics assay captured on the CellScape Spatial Proteomics Instrument (inset) using EpicIF technology (Photo: Business Wire)
AMSTERDAM (AP) — Israeli fans and protesters clashed overnight after a soccer match in Amsterdam, leaving five people hospitalized and 62 arrested, police said Friday. Dutch authorities said attackers systematically targeted Israeli fans.
It was not clear how the violence began. Dutch and Israeli leaders denounced the violence as antisemitic. Video also showed Israeli fans chanting anti-Arab slogans in the streets at some point.
Amsterdam Mayor Femke Halsema told reporters Friday that the Dutch counterterror watchdog said there was no concrete threat to Israeli soccer fans before the game.
Peter Holla, the city's acting police chief, said at the news conference that the fans were “willfully attacked."
Condemnation of the violence poured in from Jewish groups. Israel's foreign minister left on an urgent diplomatic trip to the Netherlands. Security concerns have shrouded matches with Israeli teams in multiple countries over the past year because of global tensions linked to the wars in the Middle East.
The Amsterdam police said in a post on social media platform X that they have started a major investigation into multiple violent incidents. The post did not provide further details about those injured or detained in Thursday night’s violence following the Europa League match between Ajax and Maccabi Tel Aviv.
Authorities said extra police would patrol Amsterdam in coming days, and security will be beefed up at Jewish institutions in the city that has a large Jewish community and was home to Jewish World War II diarist Anne Frank and her family as they hid from Nazi occupiers.
Earlier, a statement issued by the Dutch capital’s municipality, police and prosecution office said that the night “was very turbulent with several incidents of violence aimed at Maccabi supporters'' after antisemitic rioters “actively sought out Israeli supporters to attack and assault them.''
It was not immediately clear when and where violence erupted after the match.
“In several places in the city, supporters were attacked. The police had to intervene several times, protect Israeli supporters and escort them to hotels. Despite the massive police presence in the city, Israeli supporters have been injured,” the Amsterdam statement said.
“This outburst of violence toward Israeli supporters is unacceptable and cannot be defended in any way. There is no excuse for the antisemitic behavior exhibited last night,” it added.
The violence erupted despite a ban on a pro-Palestinian demonstration near the soccer stadium imposed by Amsterdam Mayor Femke Halsema, who had feared that clashes would break out between protesters and supporters of the Israeli soccer club.
There were also incidents involving fans ahead of the match. Dutch broadcaster NOS reported that a Palestinian flag was ripped off a building in the center of the city and riot police blocked pro-Palestinian supporters trying to march toward the Johan Cruyff Arena stadium where the match was being played.
Israel initially ordered that two planes be sent to the Dutch capital to bring the Israelis home, but later the prime minister's office said it would work on "providing civil aviation solutions for the return of our citizens.''
A statement from Prime Minister Benjamin Netanyahu's office said that “the harsh pictures of the assault on our citizens in Amsterdam will not be overlooked," and that Netanyahu "views the horrifying incident with utmost gravity." He demanded that the Dutch government take “vigorous and swift action" against those involved.
Netanyahu's office added that he had called for increased security for the Jewish community in the Netherlands.
Dutch Prime Minister Dick Schoof said on X that he followed reports of the violence “with horror.”
“Completely unacceptable antisemitic attacks on Israelis. I am in close contact with everyone involved,” he added, saying that he had spoken to Netanyahu and “emphasized that the perpetrators will be tracked down and prosecuted. It is now quiet in the capital.”
Security issues around hosting games against visiting Israeli teams led the Belgian soccer federation to decline to stage a men’s Nations League game in September. That game against Israel was played in Hungary with no fans in the stadium.
The violence in Amsterdam will no doubt lead to a review of security at upcoming matches involving Israeli teams.
European soccer body UEFA announced already on Monday that Maccabi’s next Europa League match, scheduled in Istanbul on Nov. 28 against Turkish team Besiktas, would be moved to a yet-to-be-decided neutral venue “following a decision by the Turkish authorities.”
Meanwhile, Israel’s national team is scheduled to play France in Paris next Thursday in the Nations League.
In this image taken from video, police stand guard as Maccabi Tel Aviv supporters light flares at the Dam square, in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
In this image taken from video, police escort Maccabi Tel Aviv supporters to the metro, after pro-Palestinian supporters marched near the soccer stadium, in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
In this image taken from video, police detain a person next to the place where Maccabi Tel Aviv supporters gather ahead of the Europa League soccer match between their team and Ajax, in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
In this image taken from video, pro-Palestinian supporters march with Palestinian flags near the Ajax stadium in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
In this image taken from video, police frisk pro-Palestinian supporters near the Ajax stadium in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
In this image taken from video, police detain a man near the Ajax stadium, after pro-Palestinian supporters marched despite a ban on pro-Palestinian demonstrations near the soccer stadium, in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
In this image taken from video, police stand guard forming a line near the Ajax stadium, in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
In this image taken from video, police escort Maccabi Tel Aviv supporters to the metro station leading them to the Ajax stadium, after pro-Palestinian supporters marched near the stadium, in Amsterdam, the Netherlands, Thursday, Nov. 7, 2024. (AP Photo InterVision)
