BARCELONA, Spain--(BUSINESS WIRE)--Nov 11, 2024--
Almirall, S.A. (ALM), a global biopharmaceutical company based in Barcelona, today announced its year to date financial results at the third quarter of 2024. Almirall continued to deliver strong sales growth in the first nine months of 2024 which were driven by the dermatology business, and especially the biologics portfolio in Europe. Net Sales increased by 7.9% YoY to a total of €727.6 MM, EBITDA was €142.2 MM (increase of 2.9% YoY) driven by higher sales growth, with a gross margin of 64,8%. Dermatology sales in Europe increased by 21.9% to a total of €355.2 MM. Almirall re-iterates its guidance for 2024 delivering high single digit net sales growth and an EBITDA between €175 MM and €190 MM.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20241110301062/en/
The successful launch of Ebglyss® in the first markets in Europe generated €20.4 MM in the initial nine months of 2024, representing a 34% sales increase quarter-on-quarter. The potential of lebrikizumab as a first line treatment for moderate to severe atopic dermatitis is demonstrated by the steadily increasing prescriptions in Germany, high product awareness, and strong feedback received from dermatologists and their patients - leading to significant gain of share in the dynamic market segment. The geographic expansion of lebrikizumab after the initial launch in Germany is progressing well with recent launches in Norway, UK, Spain, Denmark, and the Czech Republic. Ebglyss® is on track to deliver against expectations for 2024 and anticipated peak sales supported by continued significant investment behind the launch by Almirall.
Ilumetri®, for the treatment of psoriasis, continued to deliver very strong results gaining market share in key countries across Europe. Total sales of tildrakizumab in the first 9 months of 2024 were €152.5 MM representing a 24.8% growth year-on-year. With its steadily growing market share, Ilumetri® has cemented its strong position within the leading class of the Anti-IL 23 psoriasis treatments and is on track to achieve €250 MM peak sales.
Almirall´s broad dermatology product portfolio continues to show strong performance growing 17.3% to a total of €404.9 MM in the first nine months of 2024 further driving the company´s relevance to patients and dermatologists. Wynzora® grew 62.7% YoY to a total of €19.2 MM, and Klisyri® grew 14.0% YoY to a total of €16.4 MM.
“ Our continued strong performance at Q3 2024 is fuelled by the growth of our biologics: the sustained performance of Ilumetri®, and the positive trajectory of Ebglyss®. In combination with the success story of our broad dermatology portfolio in Europe, this growth is proof of our strong commercial capabilities and builds the foundation of our leadership in medical dermatology in line with our company ambition. In the 80 th anniversary of Almirall, we are pleased to confirmour guidance for 2024 based on this strong business performance while we continue to invest significantly in supporting our launches and R&D to advance science and to innovate for future growth.”Carlos Gallardo, Almirall Chairman and CEO
R&D pipeline
Almirall’s continued investment in its leading R&D capabilities, and the medical dermatology pipeline are closely aligned with the company’s long-term view on its contributions and commitment to positively impacting patients and society. In the YTD2024 Almirall invested 12.4% of Net Sales in R&D (representing an increase of 14.9% year on year) and major achievements in Q3 2024 – in addition to progress of the early-stage pipeline - included the completion of the decentralised regulatory procedure of our efinaconazole asset for the treatment of onychomycosis in Europe. The launch of Klisyri® large field in the USA following the approval by the FDA in June increases the potential of this product given the dermatologists’ treatment needs and the growing prevalence of Actinic Keratosis in an ageing population. Clinical testing to expand the Klisyri® indication to include large field in Europe are under way. Phase I clinical testing of the readthrough inducer for rare dermatology indications was initiated (aimed at developing an oral therapy to overcome nonsense mutations that cause a premature stop codon resulting in nonfunctional protein production). Lifecycle management activities will further strengthen Almirall´s key priority products with several ongoing clinical studies supporting Ebglyss® and Ilumetri®.
Financial highlights (€ rounded million)
2024 Full Year Guidance
Full year guidance reiterated: Net Sales growth of high-single digit and EBITDA between €175 MM - €190 MM.
Partnership with the dermatology community
Almirall´s close collaborations with dermatologists and life-science experts continue to be a key cornerstone for the company´s dedication to and success in medical dermatology. These partnerships expand Almirall´s focus on fostering scientific exchange and to advance the understanding of skin diseases, treatment options, and their impact on patients. In October, Almirall hosted the 3 rd ImmunoSkin Conference in Barcelona, which brought together leading experts and dermatologists to advance the understanding of immune-mediated skin diseases and their treatment. Almirall had a significant presence at the 33 rd congress of the European Academy of Dermatology and Venerology (EADV) in September. Amongst the 34 abstracts presented were new data showing that Ebglyss® provided sustained disease control for up to three years in more than 80% of adults and adolescents with moderate-to-severe atopic dermatitis. New data on Ilumetri® from the POSITIVE study showed the significant impact of the treatment for moderate to severe psoriasis on patients’ wellbeing.
At the Fall Clinical conference in October, Almirall´s partner Lilly presented important data showing the strong performance of Ebglyss® in patients with skin of colour, and in patients who had previously discontinued treatment with dupilumab.
About Almirall
Almirall is a global pharmaceutical company dedicated to medical dermatology. We closely collaborate with leading scientists, healthcare professionals, and patients to deliver our purpose: to transform the patients' world by helping them realize their hopes and dreams for a healthy life. We are at the forefront of science to deliver ground-breaking, differentiated medical dermatology innovations that address patients´ needs.
Almirall, founded in 1944 and headquartered in Barcelona, is publicly traded on the Spanish Stock Exchange (ticker: ALM). Almirall (total revenue in 2023: €898.8 MM, 1900 employees globally) has direct presence in 21 countries and marketed products in over 100.
For more information, please visit almirall.com.
Legal Notice
This document includes only summary information and does not intend to be comprehensive. Facts, figures and opinions contained herein, other than historical, are "forward-looking statements". These statements are based on currently available information and on best estimates and assumptions believed to be reasonable by the Company. These statements involve risks and uncertainties beyond the Company's control. Therefore, actual results may differ materially from those stated by such forward-looking statements. The Company expressly disclaims any obligation to review or update any forward-looking statements, targets or estimates contained in this document to reflect any change in the assumptions, events or circumstances on which such forward-looking statements are based unless so required by applicable law.
Almirall HQ in Barcelona (Photo: Business Wire)
Israeli airstrikes killed at least 18 people in the Gaza Strip on Thursday, including three children and two high-ranking officers in the Hamas-run police force, according to Palestinian and hospital officials.
One strike early Thursday hit a tent in an Israeli-declared humanitarian zone known as Muwasi, where hundreds of thousands of displaced people are sheltering in tents during the cold and rainy winter.
Another strike killed at least eight Palestinians in the central Gaza Strip. The dead were members of local committees that help secure aid convoys, according to Al-Aqsa Martyrs Hospital, which received the bodies. An Associated Press reporter at the hospital confirmed the toll.
There was no immediate comment from the Israeli military on the strikes.
Israel’s offensive has killed over 45,000 Palestinians in Gaza, according to local health officials, who say women and children make up more than half the fatalities. The officials do not distinguish between civilians and combatants in their tally.
The war was sparked by Hamas-led militants' Oct. 7, 2023 attack into Israel. They killed some 1,200 people, mostly civilians, and abducted around 250 that day. Around 100 hostages are still inside Gaza, at least a third of whom are believed to be dead.
Here's the latest:
JERUSALEM -- The Israeli military has claimed responsibility for a nighttime raid in Syria last September in which it says dozens of commandos destroyed a top-secret Iranian-led missile factory.
Israeli military spokesman Lt. Col. Nadav Shoshani said Thursday that Iran, working with its Syrian and the Hezbollah allies, planned to build hundreds of precision guided missiles per year at the factory that could be transferred to Lebanon. He said the facility was located in western Syria around the town of Masyaf near the Lebanese border.
He said Israel had been monitoring the underground facility for several years, but decided to strike at a time when Israel was at war with Hezbollah and the factory was becoming operational.
“This facility posed a clear threat to the state of Israel and this is why we had to take action,” he said.
Shoshani said over 100 special force soldiers took part in the Sept. 8 raid, backed by dozens of aircraft. Calling it one of Israel’s most complex operations in years, he said soldiers arrived by helicopter and entered the facility, which he said was dug deep into the side of a mountain.
In bodycam footage released by the Israeli military, special forces are seen moving through wide underground hallways and seizing documents, before a large explosion destroys the site. The video, which could not be independently verified, also showed images of what the army said was missile-manufacturing equipment.
At the time, Syrian state media reported four deaths from a series of Israeli airstrikes in the area. Shoshani said there were no Israeli casualties, and that Israel also damaged another missile-production facility in Lebanon during the war.
Israel and Hezbollah reached a cease-fire in late November, halting nearly 14 months of fighting.
JERUSALEM — Israeli Prime Minister Benjamin Netanyahu was released from the hospital Thursday after recovering from prostate surgery Sunday.
Doctors at Hadassah Ein Kerem Hospital said Netanyahu was recuperating satisfactorily, although he still has a period of recovery ahead. Medical follow-ups will continue as usual, according to a hospital statement.
Despite doctor’s orders to remain hospitalized, the 75-year-old leader had briefly left the facility to participate in a vote in Israel’s parliament on Tuesday.
KYIV, Ukraine – Ukraine’s president says his country is poised to reestablish diplomatic ties with Syria after the fall of President Bashar Assad and sharply increase agricultural exports to Lebanon despite being engaged in an almost three-year war with Russia.
The developments came after a recent visit to those countries by Ukraine’s top diplomat and its government minister for farming, according to a statement from Ukrainian President Volodymyr Zelenskyy on Thursday. Ukraine is aiming to build up its security and trade relations in the Middle East, he said.
Ukraine and Syria are assessing cooperation within international organizations, and Syria could this year become a “reliable partner” for Ukraine, Zelenskyy said.
The Ukrainian officials met with Syria’s new de facto authorities led by the Islamist group Hayat Tahrir al-Sham. The insurgents had ousted Assad, a longtime ally of Russian President Vladimir Putin, in early December.
Ukrainian agricultural exports to Lebanon are around $400 million a year but Zelenskyy said he hopes to at least double that.
Ukraine is a leading world producer of wheat, corn, barley, sunflower oil and other food products.
JERUSALEM — The Israeli military says it targeted a senior member of Hamas’ internal security apparatus in a strike in the Gaza Strip that Palestinian officials say killed nine other people, including three children.
The strike early Thursday hit a tent in an Israeli-declared humanitarian zone known as Muwasi, where hundreds of thousands of displaced people are sheltering in tents during the cold and rainy winter.
The military said Hossam Shahwan, a senior officer in the Hamas-run police force in Gaza, was involved in gathering intelligence used by Hamas’ armed wing in attacks on Israeli forces.
Maj. Gen. Mahmoud Salah, another senior police official, was also killed in the strike.
The military says Hamas militants hide among civilians and blames the group for their deaths in the nearly 15-month war, which was ignited by Hamas’ Oct. 7, 2023 attack into Israel.
The Hamas-run government had a police force numbering in the tens of thousands that maintained a high degree of public security before the war while also violently suppressing dissent.
The police have largely vanished from the streets in many areas after being targeted by Israel, contributing to the breakdown of law and order that has hindered the delivery of desperately needed humanitarian aid.
DAMASCUS, Syria — The forces together with armed vehicles were deployed in the city of Homs Thursday to look for the militants affiliated with ousted President Bashar Assad, state media reported.
SANA, citing a military official, said that the new de facto authorities led by the Islamist group Hayat Tahrir al-Sham had set up centers in Syria’s third-largest city for former soldiers and militants to hand over their weapons, similar to other parts of Syria.
In early December, a lightning insurgency took out the decades-long rule of Assad in less than two weeks. HTS has since run much of war-torn Syria under the authority of its leader Ahmad al-Sharaa.
Officials who were part of Assad's notorious web of intelligence and security apparatus have been arrested over the past few weeks.
DEIR AL-BALAH, Gaza Strip: An Israeli strike has killed at least eight Palestinian men in the central Gaza Strip.
The dead were members of local committees that help secure aid convoys, according to Al-Aqsa Martyrs Hospital, which received the bodies. An Associated Press reporter at the hospital confirmed the toll.
Earlier on Thursday, an Israeli airstrike in southern Gaza killed at least 10 people, including three children and two senior officers in the Hamas-run police.
There was no immediate comment from the Israeli military on the strikes.
Israel has repeatedly targeted the police, contributing to a breakdown of law and order in the territory that has made it difficult for humanitarian groups to deliver aid. Israel accuses Hamas of hijacking aid for its own purposes.
DUBAI, United Arab Emirates — Al Jazeera has condemned the Palestinian Authority’s decision to bar it from operating in the occupied West Bank, saying the decision was “in line” with similar actions taken by Israel.
In a statement Thursday, the Qatar-based broadcaster accused the Western-backed authority of seeking to “hide the truth about events in the occupied territories, especially what is happening in Jenin and its camps.”
The Palestinian Authority, which cooperates with Israel on security matters, launched a rare crackdown on anti-Israel militants in the urban Jenin refugee camp last month. The authority has international support but is unpopular among many Palestinians, with critics portraying it as a subcontractor of the Israeli occupation.
The Palestinian Authority announced the suspension of Al Jazeera’s activities on Wednesday, accusing it of incitement and interfering in Palestinian internal affairs. The Palestinian Authority exercises limited autonomy in parts of the Israeli-occupied West Bank.
Israel banned Al Jazeera last year, accusing it of being a mouthpiece of Hamas. Israeli strikes have killed or wounded several Al Jazeera reporters in Gaza, and Israel has accused some of them of being militants. Israeli forces raided Al Jazeera’s West Bank headquarters last year, but the broadcaster has continued to operate in the territory.
Al Jazeera denies the allegations and accuses Israel of trying to silence its coverage. Its 24-hour reporting from Gaza has focused on the deaths of Palestinian civilians. It has also broadcast Hamas and other militant videos in their entirety, showing attacks on Israeli forces and hostages speaking under duress.
Palestinian children play next to a building destroyed by Israeli army strikes in the central Gaza Strip town of Khan Younis, Wednesday, Jan. 1, 2025. (AP Photo/Abdel Kareem Hana)
Israeli soldiers stand in a bullet-ridden house during a tour for army personnel to observe the damage caused by the Oct. 7 Hamas onslaught at Kibbutz Kfar Aza, near the Israeli-Gaza border, in Israel, Thursday, Jan. 2, 2025. (AP Photo/Matias Delacroix)
An Israeli soldier jumps off an armoured vehicle at a staging area near the Gaza border in southern Israel, Thursday Jan. 2, 2025. (AP Photo/Tsafrir Abayov))
Palestinians prepare the body for the funeral of a man killed during an Israeli army strike in Deir al-Balah in the central Gaza Strip, Thursday Jan. 2, 2025. The strike killed at least eight men members of local committees that help secure aid convoys, according to the Al-Aqsa Martyrs Hospital, which received the bodies.(AP Photo/Abdel Kareem Hana)
A man reacts in grief as the body of 8-year-old Adam Farajallah is brought to Al-Aqsa Martyrs Hospital following an airstrike on a house in the Bureij refugee camp, in the central Gaza Strip town of Deir al-Balah Wednesday, Jan. 1, 2025. (AP Photo/Abdel Kareem Hana)
A man mourns over the body of a Palestinian man killed during an Israeli army strike in Deir al-Balah in the central Gaza Strip, Thursday Jan. 2, 2025. The strike killed at least eight men members of local committees that help secure aid convoys, according to the Al-Aqsa Martyrs Hospital, which received the bodies.(AP Photo/Abdel Kareem Hana)
Palestinian girls collect donated food at a food distribution center in Deir al-Balah, central Gaza Strip, Thursday Jan. 2, 2025. (AP Photo/Abdel Kareem Hana)
An Israeli soldier covers his ears as an artillery gunner fires into the Gaza Strip from a position in southern Israel, Thursday, Jan. 2, 2025.(AP Photo/Matias Delacroix)
A destroyed part of Gaza City as seen from southern Israel, Thursday Jan. 2, 2025. (AP Photo/Tsafrir Abayov))
Palestinians inspect the site of an earlier Israeli army strike in the Muwasi area, in Khan Younis, central Gaza Strip, Thursday Jan. 2, 2025. According to Palestinian medical officials, the airstrike killed at least 10 people, including three children and two senior police officers, in an Israeli-designated humanitarian zone in the Gaza Strip. (AP Photo/Abdel Kareem Hana)
