MANHASSET, N.Y.--(BUSINESS WIRE)--Apr 18, 2025--
Researchers at Northwell Health’sFeinstein Institutes for Medical Research found that obinutuzumab, a therapeutic antibody that depletes B cells and is approved for the treatment of B cell malignancies, benefitted patients with lupus nephritis, a severe complication of lupus that compromises kidney function.
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The study, which was led by Richard A. Furie, MD, professor in the Feinstein Institutes’ Institute of Molecular Medicine and The Marilyn and Barry Rubenstein Chair in Rheumatology, and published today in The New England Journal of Medicine, shows findings from a phase 3 clinical trial known as REGENCY. The REGENCY trial was a randomized, double-blind, placebo-controlled study conducted across 15 countries, involving 271 adults with biopsy-proven active lupus nephritis. Participants were randomly assigned to receive either obinutuzumab in addition to standard therapy (mycophenolate mofetil and glucocorticoids), or a placebo along with standard therapy.
Results showed a significantly higher percentage of participants in the obinutuzumab group achieved a complete renal response compared to the placebo group. This positive outcome translated to a clinically meaningful improvement in kidney function.
“These findings represent a major step forward in the treatment of lupus nephritis,” said Dr. Furie, who is also chief of the Division of Rheumatology at Northwell Health. “Obinutuzumab, a well-known and easy-to-obtain drug, could potentially offer new hope for patients living with this challenging condition.”
Lupus is an autoimmune disease where the body's defense system mistakenly attacks healthy tissues. When this attack targets the kidneys, it leads to lupus nephritis, causing inflammation and impaired kidney function. This can progress to serious kidney complications, including kidney failure. Many patients with lupus nephritis experience inadequate responses to standard therapies, despite receiving medications like mycophenolate mofetil and prednisone.
“Dr. Furie and his team have delivered new hope for patients with lupus nephritis, a condition where effective treatments are desperately needed,” said Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes and Karches Family Distinguished Chair in Medical Research. “This clinical trial result reveals that obinutuzumab can improve short-term outcomes while further data is being collected to determine the long-term impact the drug has on kidney health.”
About the Feinstein Institutes
The Feinstein Institutes for Medical Researchis the home of the research institutes of Northwell Health, the largest health care provider and private employer in New York State. Encompassing 50+ research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its six institutes of behavioral science, bioelectronic medicine, cancer, health system science, molecular medicine, and translational research. We are the global scientific leader in bioelectronic medicine – an innovative field of science that has the potential to revolutionize medicine. The Feinstein Institutes publishes two open-access, international peer-reviewed journalsMolecular MedicineandBioelectronic Medicine. Through theElmezzi Graduate School of Molecular Medicine, we offer an accelerated PhD program. For more information about how we produce knowledge to cure disease, visithttp://feinstein.northwell.eduand follow us onLinkedIn.
Dr. Richard A. Furie led the study. (Credit: Feinstein Institutes).
BARCELONA, Spain (AP) — This was Lamine Yamal's season.
So it just had to be the teenage phenom who scored the decisive goal to clinch Barcelona's 28th Spanish league title.
And what a goal it was for the player who still wears dental braces and sports a new dyed-blond hairdo.
The 17-year-old struck the winner in Barcelona's 2-0 victory at crosstown rival Espanyol on Thursday when he slid past two defenders outside the area and whipped one his now trademark left-footed curlers into the corner of the net.
It was a perfect culmination to Yamal's last 10 months.
After helping Spain win the European Championship last summer, Yamal excelled for Barcelona this campaign with his goals, dribbling and playmaking as he confirmed his status as the next big star of global soccer. Along with Raphinha, Pedri and company, and Barcelona was unstoppable.
“I always try my best and today I was lucky it went in,” Yamal said. "I am very happy I could help the team and celebrate it.”
Fermín López ensured the win in stoppage time after Espanyol was reduced to 10 men in the 80th when Leandro Cabrera received a direct red for hitting Yamal in the stomach while disputing a ball.
Barcelona won the title with two rounds remaining. It completed a domestic double with the Copa del Rey title — treble if you add the Spanish Super Cup — and reached the Champions League semifinals in a fantastic first season for coach Hansi Flick.
Flick’s team virtually ended Madrid’s title defense when it beat its top rival 4-3 on Sunday, making it four of four clasico victories across all competitions this season.
Madrid's victory over Mallorca on Wednesday prevented Barcelona from winning the title without playing. But the Catalan club needed just two points from its final three games of the season.
Barcelona’s players danced briefly on the field to celebrate while sprinklers doused them with water.
“You don’t win a league every day and we have to enjoy this and give it the value it has,” said Barcelona midfielder Pedri after completing his 200th game for his club at age 22.
Lionel Messi posted a message on Instagram sending his “Congratulations” for his old team. Real Madrid also congratulated its fierce rival on X, while thousands of Barcelona fans gathered to celebrate in downtown Barcelona.
Barcelona dominated the domestic competitions, winning 15 and drawing two of its league games in 2025. Toss in the cups, and the only tiny blemish was coming oh-so-close to reaching the Champions League final before it fell in gut-wrenching fashion at Inter Milan.
Yamal credited his coach for inspiring a core of players who had won nothing last season under Xavi Hernández.
“We are thankful for what Xavi have us, but it is true that coach (Flick) has given us a new life,” Yamal said.
Looking back on his arrival in the summer, Flick said that he had instilled a “positive” attitude in his team and it had adapted well to his style of play that requires a high defensive line and all-in pressing.
“Barcelona has to win titles and three titles is really great,” Flick said. “I suffered a bit after the game in Milan, but after winning three titles I am very happy and the club is too.”
Espanyol outplayed its wealthier rival in the first half. But Urko González shot wide on a counterattack early on and Javi Puado couldn’t beat Wojciech Szczesny in a one-on-one opportunity.
But Yamal's great shot in the 53rd minute put Barcelona in control. Espanyol goalkeeper Joan García, who is linked to a move to a big club this summer, including Barcelona, dove but couldn’t reach the perfectly placed shot.
On Yamal’s goal, Pedri said: “He scored two goals like that today in practice. We are fortunate to have him on our side.”
Espanyol needed to a good result from the derby as it hopes to stay out of the relegation fight. Espanyol remained in 16th place and five points from the drop zone.
The game was briefly paused by the referee in the opening minutes when a car rammed into a crowd outside the RCDE Stadium, injuring several people. Authorities said it was an accident and not related to the game.
Fourth-placed Athletic Bilbao secured a Champions League spot after winning 2-0 at Getafe.
Third-placed Atletico Madrid lost 2-0 at Osasuna, while Real Betis stumbled in its fight for a fifth-place finish and the last Champions League spot after drawing 2-2 Rayo Vallecano.
AP soccer: https://apnews.com/hub/soccer
Barcelona's Lamine Yamal reacts after scoring during a Spanish La Liga soccer match between Espanyol and Barcelona in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Jose Breton)
Barcelona fans celebrate in the street after their team won the Spanish La Liga soccer championship in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Emilio Morenatti)
Barcelona's Hector Fort celebrates at the end of the Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona players celebrate at the end of the Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona players celebrate after a goal during a Spanish La Liga soccer match between Espanyol and Barcelona in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Jose Breton)
Barcelona's Fermin Lopez, celebrates after scoring his side's second goal during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal reacts after scoring during a Spanish La Liga soccer match between Espanyol and Barcelona in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Jose Breton)
Espanyol's Antoniu Roca, left, attempts a shot at goal in front of Barcelona's Gerard Martin during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Espanyol's Javi Puado, left, attempts a shot at goal in front of Barcelona's Andreas Christensen during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal, left, celebrates with his teammates after scoring his side's opening goal during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal spits out water as he warms up prior to a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal drinks water as he warms up prior to a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal, center, celebrates after scoring his side's opening goal during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal, left, runs with the ball past Espanyol's Carlos Romero during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal, left, celebrates with his teammate Alejandro Balde after scoring his side's opening goal during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
Barcelona's Lamine Yamal attempts a shot at goal to scores his side's opening goal during a Spanish La Liga soccer match between Barcelona and Espanyol at Lluis Companys Olympic Stadium in Barcelona, Spain, Thursday, May 15, 2025. (AP Photo/Joan Monfort)
