SEOUL, South Korea, Dec. 18, 2024 /PRNewswire/ -- The Incheon Free Economic Zone Authority (IFEZ) will make a strong comeback at CES 2025, which will be held from January 7 to 10 in Las Vegas. Under the theme "Urban Renaissance: Building Tomorrow's Smart Cities Today," IFEZ will showcase its smart city vision and highlight cutting-edge technologies from 41 innovative companies.
The Incheon-IFEZ pavilion in the AI Zone of the North Hall at the Las Vegas Convention Center will spotlight ten leading Incheon-based startups specializing in AI, urban tech, and smart city solutions. Beyond the pavilion, ten companies will join the Eureka Park Korea Pavilion, six will exhibit at the Global Pavilion, and 15 more will participate as part of a broader delegation.
This extensive representation underscores Incheon's emergence as a tech innovation hub, reflecting its global ambitions and technological prowess.
The Incheon-IFEZ pavilion promises to be more than just an exhibition space. It will transform into a dynamic networking hub where global business leaders, investors, and innovators can explore potential collaborations with Incheon-based companies.
The pavilion's first major event, the Unveiled Incheon Media Stage, will introduce IFEZ's forward-thinking smart city vision to international media outlets on January 7. All Connected Incheon Night will bring together global investors, entrepreneurs, and industry leaders to foster meaningful partnerships that evening.
The momentum continues on January 8 with the IFEZ Tech Talk, featuring industry giants like LG Electronics, Lotte Innovate, and the Stanford Center at Incheon Global Campus. They will present insights into IFEZ's smart city projects and innovation initiatives.
On January 9, the spotlight will shift to the IFEZ Showcase, a pitching competition where Incheon's top startups will present their groundbreaking technologies to over 30 global venture capital investors. This event aims to secure international partnerships and expand market reach.
IFEZ's continued participation at CES reflects its commitment to driving global innovation. Established in 2003 as South Korea's first free economic zone, IFEZ encompasses Songdo, Yeongjong, and Cheongna. Designed to stimulate economic growth, its advanced infrastructure and prime location have made it a thriving business hub over the past two decades.
By participating in CES 2025, IFEZ reaffirms its dedication to fostering innovation and connecting visionary startups with the global market. The official CES 2025 Incheon-IFEZ website, www.ces2025-ifez.com, provides more details.
Media and Interview Contact
Don Southerton, CES 2025 Incheon-IFEZ
Dsoutherton@bridgingculture.com
+1 310-866-3777
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Incheon's Bold Return to CES 2025: Pioneering Tomorrow's Smart Cities
HONG KONG, Dec. 23, 2024 /PRNewswire/ -- A research led by Hong Kong Baptist University (HKBU) and the Shanghai Sixth People's Hospital Affiliated to School of Medicine at Shanghai Jiao Tong University (Shanghai Sixth People's Hospital) has discovered that an aptamer developed by HKBU can be used to treat X-linked hypophosphatemia (XLH), a rare bone disease. The aptamer, originally developed to treat osteogenesis imperfecta, has been granted Orphan Drug Designation and Pediatric Rare Disease Designation by the U.S. Food and Drug Administration (FDA).
XLH ("X" denotes X-chromosome, a sex-determining chromosome) is a rare bone disease characterised by hypophosphatemia (i.e., low phosphate in blood). It is caused by a mutation in the phosphate regulating endopeptidase homolog X-linked (PHEX) gene, and its inheritance pattern follows an X-linked dominant mode. The bone tissue of XLH patients cannot mineralise properly, thereby affecting the hardness of the bones. The cartilage between the ribs of children with XLH grows and connects like beads strung together. They also result in limb deformities and growth retardation. Adult patients experience symptoms such as osteomalacia, bone pain, changes in body shape, shorter stature and pseudo-fractures, leading to reduced mobility or even disability.
Professor Zhang Ge, Associate Dean (Research) of Chinese Medicine and Director of the Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases at HKBU, and Professor Zhang Zhenlin, Director of Osteoporosis and Bone Diseases of the Shanghai Sixth People's Hospital, along with Aptacure Therapeutics Ltd., have developed a long-acting sclerostin-loop3 oligonucleotide aptamer for the treatment of XLH. This aptamer has been granted Orphan Drug Designation and Pediatric Rare Disease Designation by the U.S. FDA for treatment of XLH earlier this year.
Researchers conducted serum tests on 51 patients with XLH from the Shanghai Sixth People's Hospital. The results showed that their serum sclerostin levels were approximately 4.5 times higher than those of healthy individuals of the same age and gender.
Sclerostin is a protein that inhibits bone growth while playing a protective role in the cardiovascular system. Genetic evidence shows that sclerostin deficiency significantly elevates serum phosphorus levels and increases bone mass in mice. However, the monoclonal sclerostin antibody currently used increases the risk of heart attacks, stroke and cardiovascular diseases.
The research team discovered that sclerostin inhibits bone formation and protects the cardiovascular system through different domains of the protein. When sclerostin loses the "loop3 domain", bone mass and strength increase, but its cardiovascular protective effect remains unaffected. The "loop3 domain" of sclerostin can therefore serve as a therapeutic molecular target to promote bone formation, with no safety concern in the cardiovascular system.
The researchers then screen out oligonucleotide aptamers Apc001 that can inhibit the sclerostin loop3. Animal experiments showed that Apc001 can promote bone formation without increasing cardiovascular risk. It can also significantly increase the blood phosphorus levels of mice with XLH. This is expected to provide a drug candidate for the precise treatment of XLH patients.
According to the regulations of the U.S. FDA, once a drug under development obtains Orphan Drug Designation, its subsequent research and development may allow for a reduction in the number of clinical trial samples, be exempt from new drug marketing authorisation fees, and enjoy seven years of market exclusivity. Pediatric Rare Disease Designation allows drugs to be reviewed with priority. Having been designated as both an orphan drug and a pediatric rare disease by the U.S. FDA, Apc001 can accelerate its clinical translation and is expected to benefit patients with XLH sooner.
Currently, the pilot scale production of Apc001 has been completed and is undergoing the preclinical toxicological assessment by a third party. Apc001 is scheduled to enter clinical trials in both Mainland China and the U.S.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Aptamer developed by HKBU for treating rare bone disease 'X-linked hypophosphatemia' receives Orphan Drug Designation and Rare Pediatric Disease Designation by U.S. FDA
