GUANGZHOU, China, Jan. 7, 2025 /PRNewswire/ -- The first phase of the 55th edition of the China International Furniture Fair (Guangzhou) (CIFF Guangzhou 2025), featuring Home Furniture, is set to take place from March 18 to 21, 2025, at the Canton Fair Complex in Guangzhou. This prestigious event will bring together industry leaders, designers, and consumers to explore the latest trends and innovations in the furniture sector.
The exhibition will feature distinct sections, each showcasing various facets of the home furniture industry. Highlights include design and upholstery, dining and living rooms, home accessories, textiles, and outdoor furniture. A Suite Furniture section will also be included, offering opportunities for companies targeting domestic growth, export, and cross-border e-commerce specialists.
The fair will spotlight design as a pivotal force in the industry, showcasing exhibitions focused on contemporary aesthetics and soft furnishings. It will also feature discussions on Chinese home design, trends, craftsmanship, materials, and the role of AI in furniture design. This theme will permeate the event, encouraging participants to explore the future of sustainable design practices.
The living room section will spotlight the sofa as the centerpiece, occupying a vast 90,000 square meters. This area will particularly address the needs of younger consumers, exploring how sofas can create emotional connections with users, incorporate smart innovations, and be pet-friendly. These discussions aim to redefine the role of the sofa in modern living spaces, making it more than just a piece of furniture but a central element of home life.
The bedroom section will emphasize sleep, dedicating 40,000 square meters to this vital aspect of life. Beyond traditional categories, it will feature new segments like smart sleep solutions, sleep ecosystems, and community care solutions for the elderly. These innovations highlight the increasing consumer interest in improving sleep quality and well-being through thoughtful bedroom design.
Additionally, the international pavilion will cater to both international and domestic markets. It will showcase global furniture brands and international exhibitors, creating a precise and efficient procurement platform for global buyers. This section aims to foster cross-cultural exchange and present diverse lifestyle scenarios, highlighting the interconnectedness of the global furniture market.
As March approaches, CIFF Guangzhou 2025 is ready to welcome global participants. The event promises to be a dynamic event, offering a comprehensive view of the current and future landscape of the furniture industry.
Visit https://www.ciff-gz.com/en/ for more information.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
CIFF Guangzhou 2025 Preview: A Focus on Creative Design and Trade Upgrades
YANTAI, China, Jan. 8, 2025 /PRNewswire/ -- On Janurary 7th, 2025, Annals of Oncology (IF: 56.7), a top oncology journal globally, published remarkable long-term follow-up results of a phase 1b/2 clinical trial on Disitamab Vedotin (DV) (developed by Remegen Co., Ltd) combined with Toripalimab in treating locally advanced or metastatic urothelial carcinoma (la/mUC) (NCT04264936, study ID: RC48-C014). This trial was supervised by Professor Jun Guo and Professor Xi'nan Sheng's teams from Peking University Cancer Hospital.
It is the first time that long-term follow-up data has been released for a HER2-targeted antibody-drug conjugate (ADC) and PD-1 inhibitor combination therapy in treating la/mUC, marking it a significant milestone. The nearly-three-year follow-up data revealed an objective response rate (ORR) of 73.2% and median overall survival (OS) of 33.1 months, superior to data published from any other prospective clinical studies on ADC plus PD-1 combination therapies for la/mUC.
New Treatment Options for Patients with La/mUC
UC is the sixth most common cancer worldwide. GLOBOCAN 2022 estimated the year 2021 saw 614,298 new cases and 220,596 deaths of UC. In recent years, the prognosis for patients with la/mUC has significantly improved with new drugs and combination therapies approved, among which ADCs demonstrated outstanding potential.
As a HER2-targeted ADC, DV has been approved in China for patients with HER2-overexpressing (defined as immunohistochemistry [IHC] test results of 2+ or 3+) la/mUC previously treated with platinum-containing chemotherapy. The approval is based on the pooled results of two studies (NCT03507166 and NCT03809013, study IDs: RC48-C005 and RC48-C009) where the ORR registered 50.5% and the median duration of response (DOR) registered 7.3 months.
Multiple clinical studies on la/mUCin recent years have confirmed the synergistic antitumor effects of ADC combined with immunotherapy. NCT04264936 offered stronger evidence as its long-term follow-up results published in the Annals of Oncology demonstrated the high response rate, significant survival benefits, and manageable safety profile of the DV and Toripalimab combination therapy.
DV Combined with Toripalimab: High Response Rate and Prolonged Survival
NCT04264936 is an open-label, multicenter, investigator-initiated phase 1b/2 clinical trial investigating the safety and efficacy of DV in combination with Toripalimab for the treatment of patients with HER2-expressing la/mUC. The dose-escalation study (phase 1b) assessed two dose levels of DV (1.5 and 2.0 mg/kg) combined with Toripalimab (3.0 mg/kg) to determine the recommended phase 2 dose which was then evaluated in the dose-expansion stage (phase 2).
From August 2020 to December 2021, 41 patients were enrolled with a median age of 66 years. 53.7% of the participants were male, 70.7% had an ECOG performance status score of 1, 17 (41.5%) had lung metastasis, and 10 (24.4%) had liver metastasis.
As of March 1, 2024, among all participants, the ORR was 73.2% with 4 (9.8%) achieving complete response and 26 (63.4%) achieving partial response, the DCR was 90.2%, the median progression-free survival (PFS) was 9.3 months, the median DOR was 8.6 months, the median OS was 33.1 months and the 36-month OS rate was 49.2%.
Subgroup analysis revealed ORR benefits across all subgroups regardless of the number of prior lines of systemic treatments, HER2 expression (IHC 1+/2+/3+), and PD-L1 expression status. The ORRs for chemotherapy-naïve patients and those who progressed on platinum-based chemotherapy were 76.0% (19/25) and 68.8% (11/16), respectively. The ORRs for patients with HER2 IHC 3+, 2+, 1+, or 0 were 80.0%, 84.2%, 64.3%, and 33.3%, respectively. Compared with the three HER2 IHC 0 participants (one of whom achieved partial response), those with HER2 expression (IHC 1+/2+/3+) had a higher ORR (76.3% vs 33.3%) and longer PFS (median PFS: 9.3 vs 1.7 months).
In summary, the DV and Toripalimab combination therapy has preliminarily demonstrated promising efficacy and manageable safety profile among patients with la/mUC, wherein those with HER2 expression (IHC 1+/2+/3+) achieved high response rates and long-term survival benefits. These findings support the further exploration and validation of the benefits of DV combined with PD-1 inhibitors in treating la/mUC.
** The press release content is from PR Newswire. Bastille Post is not involved in its creation. **
Published in Annals of Oncology: Disitamab Vedotin Combined with PD-1 Inhibitor is a Promising Treatment for Locally Advanced or Metastatic Urothelial Carcinoma
