TOKYO--(BUSINESS WIRE)--Mar 17, 2025--
Neutrophil to Lymphocyte ratio (NLR) is a critical biomarker of health of astronauts during space mission, and that of aging related illnesses, inflammaging, longevity and cancer prognosis. Oral consumption of AFO-202 strain of Aureobasidium pullulans produced Nichi BRITE and N-163 strain produced Neu REFIX together in pre-clinical and clinical studies having safely and beneficially modified NLR, are considered holding potential to help maintain astronauts health during space flight and also to bridge the gap between health span and life span by ‘ Me-Byo’ phenomenon as published in Frontiers in Immunology while Neu REFIX standalone yielding enhanced dystrophin, an additional benefit that might help prevent muscle loss during space missions.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250316966059/en/
Astronauts during space travel are exposed to ionizing radiation, circadian rhythm disruption and microgravity leading to stress, inflammation and immune dysfunction which reflects as an increase in NLR. There has been no safe intervention using a food supplement reported yet beneficially modifying NLR, according to the authors. They added that Nichi BRITE reporting immune enhancement and anti-cancer effects, Neu REFIX for its immune modulation and anti-fibrotic effects apart from enhanced gravisensing dystrophin in pre-clinical and clinical studies; when consumed together efficiently enhances butyrate, an indicator of health and longevity through beneficial gut microbiome modulation are worth further research in simulated microgravity and for vulnerable populations, specially immunocompromised and in auto-immune diseases. These potentials may bridge the gap between health span and lifespan. Neu REFIX has been granted ODD and RPD by US FDA for treatment of Duchenne Muscular Dystrophy (DMD).
Hastening process of aging & inflammaging during space flight and muscle mass reduction similar to old age reflected by NLR and dystrophin levels, being beneficially modified by these unique exo-polysaccharide beta glucans manufactured in Japan as food supplements open a new area of research which could help space travel and also aging & longevity related health indices. Research could also be of help in the health and resilience of individuals working in harsh environmental conditions such as deep-sea researchers, high-altitude climbers, polar expeditions and workers prone to radiation hazards.
*B-1,3-1,6 glucan is alisted food additive in MHLW, Japan; Not a drug or remedy to any illness. Research findings should not be construed as medical advice. Not GRAS, EFSA certified.
Astronauts during space missions, deep-sea researchers, high-altitude climbers, and workers exposed to radiation hazards, are highly prone to hastened process of aging and inflammaging, reflected by increase in NLR, Interleukin-6, gut dysbiosis and immune dysfunction. Going by earlier pre-clinical & clinical studies where oral consumption of Nichi BRITE and Neu REFIX beta-glucans have shown to safely and beneficially modify those biomarkers including reduction of D-Dimer and Ferritin, besides Neu REFIX standalone reducing skeletal muscle fibrosis are considered holding potentials for benefitting those undertaking expeditions in hostile conditions. Upon validation, they could be included in the guidelines as an ingredient especially for space foods. These exo-polysaccharide beta glucans produced by unique strains of Aureobasidium Pullulans are food supplements and not a drug or remedy for any illness. Research outcomes are not to be construed as medical advice.
WASHINGTON (AP) — The Justice Department is resisting a federal judge's demand for more information about flights that took deportees to to El Salvador, arguing on Wednesday that the court should end its “continued intrusions” into the authority of the executive branch.
It's the latest development in a showdown between the Trump administration and the judge who temporarily blocked deportations under an 18th century wartime declaration. President Donald Trump has called for the judge's impeachment as the Republican escalates his conflict with a judiciary after a series of court setbacks over his executive actions.
U.S. District Judge Jeb Boasberg, who was nominated to the federal bench by Democratic President Barack Obama, had ordered the Trump administration to answer several questions under seal, where the information would not be publicly exposed. There were questions about the planes' takeoff and landing times, and the number of people deported under Trump’s proclamation.
The judge has questioned whether the Trump administration ignored his court order on Saturday to turn around planes with deportees headed for the Central American country, which had has agreed to house them in a notorious prison.
In court papers filed hours before the deadline to respond Wednesday, the Justice Department said the judge's questions are “grave encroachments on core aspects of absolute and unreviewable Executive Branch authority relating to national security, foreign relations and foreign policy." The department said it was considering invoking the “state secrets privilege” to allow the government to withhold some of the information sought by the court.
“The underlying premise of these orders ... is that the Judicial Branch is superior to the Executive Branch, particularly on non-legal matters involving foreign affairs and national security. The Government disagrees,” Justice Department lawyers wrote. “The two branches are co-equal, and the Court's continued intrusions into the prerogatives of the Executive Branch, especially on a non-legal and factually irrelevant matter, should end.”
Boasberg later issued an order giving the administration until Thursday at 12 p.m. EDT to either provide the requested information or make a claim that it must be withheld because it would harm “state secrets.” He took issue with the government's characterization of his request as a “unnecessary judicial fishing” expedition, saying it was necessary to “determine if the government deliberately flouted” his order to turn around the flights, “and if so, what the consequences should be.”
He also questioned how providing the information to the court could “jeopardize state secrets,” given that administration officials have already publicly released many details about the flights.
Trump invoked the Alien Enemies Act, which has only been used three times before in U.S. history, all during congressionally declared wars. and claimed there was an invasion by the Venezuelan gang Tren de Aragua.
Boasberg ordered the administration not to deport, through that 1798 law, anyone in its custody.
Told there were planes in the air headed to El Salvador, Boasberg said Saturday evening that he and the government needed to move fast. “You shall inform your clients of this immediately, and that any plane containing these folks that is going to take off or is in the air needs to be returned to the United States,” Boasberg told the government’s lawyer.
Hours later, El Salvador’s president, Nayib Bukele, said the deportees had arrived in his country. "Oopsie...too late” he said in a social media post, above an article referencing Boasberg’s original order.
The administration contends that a judge lacks the authority to tell the president whether he can determine the country is being invaded under the act, or how to defend it.
Boasberg's new order for answers came after the administration provided limited information in response to a sharp questioning from the judge at a Monday hearing.
The administration said in a filing Tuesday that two planes took off before Boasberg’s order went into effect, and a third plane that took off after the ruling came down did not include anyone deported under the law. The administration declined, however, to provide estimates about the number of people subject to the proclamation.
White House press secretary Karoline Leavitt told reporters during a Monday briefing that about 261 people were deported, including 137 under the law.
Jasmin Ramirez holds a photo of her son, Angelo Escalona, at a government-organized rally protesting the deportation of alleged members of the Venezuelan Tren de Aragua gang, who were transferred to an El Salvador prison, in Caracas, Venezuela, Tuesday, March 18, 2025. Ramirez said she hadn't heard from her son since he called to say he was with a group of migrants about to be deported on March 14. (AP Photo/Ariana Cubillos)
FILE - A mega-prison known as Detention Center Against Terrorism (CECOT) stands in Tecoluca, El Salvador, March 5, 2023. (AP Photo/Salvador Melendez, File)
