Bruker Announces Successful Installation of 1.2 GHz Avance® NMR Spectrometer at the Korea Basic Science Institute (KBSI)

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Bruker Announces Successful Installation of 1.2 GHz Avance® NMR Spectrometer at the Korea Basic Science Institute (KBSI)

2024-08-14 01:35 Last Updated At：01:41

SEOUL, South Korea--(BUSINESS WIRE)--Aug 13, 2024--

Bruker Corporation is pleased to announce the successful installation and acceptance of a 1.2 GHz Avance® Nuclear Magnetic Resonance (NMR) spectrometer at the Korea Basic Science Institute ( KBSI ), just in time before the start of the ICMRBS 2024 conference in Korea. As the first 1.2 GHz NMR system in the Asia-Pacific region, it sets a new benchmark for molecular, cell biology and disease research by ultra-high field NMR.

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This underscores KBSI’s unwavering commitment to innovation in research infrastructure, cementing its status as a world-class fundamental research institute. This cutting-edge 1.2 GHz NMR spectrometer further enhances KBSI’s capabilities in biomolecular structure analysis and drug development, pushing the boundaries of protein NMR research. Ultra-high field NMR provides excellent sensitivity and unprecedented resolution, enabling researchers to observe functional molecular dynamics and structural rearrangements in real time. Complementary to other structural biology technologies, GHz-class NMR allows KBSI to elucidate complex biological processes, such as protein-ligand interactions and the behavior of intrinsically disordered proteins, which are crucial for understanding disease mechanisms and developing new therapeutic strategies.

Dr. Hae-Kap Cheong, Manager of the UHF NMR system at KBSI, expressed his enthusiasm: “When using the 1.2 GHz instrument, the opportunities for small molecule research made me speechless. In particular, the structural elucidation of natural products will be greatly beneficial.”

Dr. Donghan Lee, Scientific Researcher at KBSI, adds: “As Richard Feynman said, ‘Everything that living things do can be understood in terms of the jiggling and wiggling of atoms.’ The function of biomolecules can be understood by their dynamic nature. In particular, the functional conformation of biomolecules may be hidden because of their dynamic nature. With the 1.2 GHz instrument, the detection of these conformations enables the unprecedented identification of functional conformations.”

KBSI is dedicated to advancing scientific research through state-of-the-art technology and innovative research facilities. As a platform for global basic research, KBSI connects research facilities, equipment, and researchers, driving the future of science and technology in the Asia-Pacific region. With its mission to lead the innovation of research facilities and equipment, KBSI continues to support advanced analytical research and joint research initiatives in Korea and beyond.

Dr. Kyoung-Seok Ryu, Director of the Biopharmaceutical Research Center at KBSI, added: “The application of the 1.2 GHz instrument includes mechanistic understanding, in particular, the mode-of-action of drug-target binding and molecular communication. Furthermore, studying intrinsically disordered or partially disordered proteins with the 1.2 GHz NMR instrument can elucidate the functional mechanisms underlying neurodegeneration.”

KBSI will utilize the 1.2 GHz spectrometer for a diverse range of research applications, including the study of biomolecular structures and the development of new drugs. This ultra-high field NMR instrument will support other KBSI research in biomedical multiomics, bioimaging, and the development of diagnostic methods for infectious diseases. The broader benefits of this research will extend to advancements in medical research, materials science, and other critical fields.

Dr. Falko Busse, President of Bruker BioSpin, commented: “We are thrilled to see the 1.2 GHz NMR become a key part of KBSI’s research infrastructure. Grateful for the trust from KBSI, we look forward to the scientific advancements that will emerge. We are pleased to offer a tour of the 1.2 GHz NMR at KBSI during the International Conference on Magnetic Resonance in Biological Systems.”

Interested researchers can book the tour at Bruker Booth A1 at ICMRBS for Friday, August 23, providing a unique opportunity to explore the advanced capabilities of this revolutionary instrument.

With the installation at KBSI, there are now 22 GHz-class NMR spectrometers installed worldwide, including two in the Asia-Pacific region. This demonstrates the growing recognition of the value GHz-class NMR brings to scientific research. Together with the first single-story 1.0 GHz NMR already installed in Japan, KBSI’s 1.2 GHz highlights the need for cutting-edge research infrastructure.

About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR)

Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit www.bruker.com.

Sweeping Trump tariffs draw dismay, calls for talks from countries around the globe

2025-04-03 20:17 Last Updated At：20:20

FRANKFURT, Germany (AP) — Sweeping new tariffs announced by U.S. President Donald Trump provoked dismay, threats of countermeasures and urgent calls for talks to find ways to rescind the stiff new import taxes imposed on goods from countries around the globe.

But responses Thursday were measured, highlighting a lack of appetite for an outright trade war with the world's biggest economy.

Trump said Wednesday the import taxes, ranging from 10% to 49%, would do to U.S. trading partners what they have long done to the U.S. He maintains they will draw factories and jobs back to the United States.

“Taxpayers have been ripped off for more than 50 years,” he said. “But it is not going to happen anymore.”

Trump's announcement of a new 20% tariff on the European Union drew a sharp rebuke from European Commission President Ursula von der Leyen, who said it was a “major blow to the world economy.”

“The consequences will be dire for millions of people around the globe,” von der Leyen said. Groceries, transport and medicines will cost more, she said while visiting Uzbekistan. “And this is hurting, in particular, the most vulnerable citizens.”

Von der Leyen held off, however, from announcing new retaliatory measures and underlined that the EU was ready to negotiate with the U.S.

The makers of Italy's Parmigiano Reggiano cheese say the new tariffs just mean U.S. consumers will pay more, since the protected designation cheese doesn't really compete with U.S. made parmesan. “Americans continued to choose us even when the price went up" after an earlier round of Trump tariffs in 2019, said Nicola Bertinelli, president of the Parmigian Reggiano Consortium.

“Putting tariffs on a product like ours, only increases the price for American consumers, without protecting local producers,’’ he said.

Analysts say there’s little to be gained from an all-out trade war, for the United States or other countries, since higher tariffs can lower growth and raise inflation.

“If Trump really imposes high tariffs, Europe will have to respond, but the paradox is that the EU would be better off doing nothing,” said Matteo Villa, a senior analyst at Italy’s Institute for International Political Studies.

“On the other hand, Trump seems to understand only the language of force, and this indicates the need for a strong and immediate response,” Villa said. “Probably the hope, in Brussels, is that the response will be strong enough to induce Trump to negotiate and, soon, to backtrack.”

Europe's strategy so far has been to limit retaliation to early tariff rounds to just a few politically sensitive goods such as bourbon and motorcycles in an attempt to push the U.S. to the negotiating table, rather than escalate an all-out trade war that could cripple its export-dependent economy.

Economists say the next target could be U.S. tech companies. They fall into the services category, where the U.S. exports more than it imports to Europe and thus would be more exposed to retaliation.

The EU response, likely to be ready by the end of April, includes the option of a tax on U.S. digital giants, said French government spokesperson Sophie Primas. “We’re going to target the services, for example, digital services which are not being taxed for now and could be, the GAFAM for example,” she said on French radio RTL. That's a colloquial acronym for Google, Apple, Facebook, Amazon and Microsoft.

Outgoing German Chancellor Olaf Scholz said the EU won’t be able to limit itself to saying the tariffs are damaging — “we must show that we have strong muscles.”

He added: “But this is with the aim of an agreement, because that is the best for prosperity in the U.S., for prosperity in Europe and for prosperity in the world.”

British Prime Minister Kier Starmer said the U.K. government would react with “cool and calm heads," telling business leaders in London that he hopes to get the tariffs lifted with a trade deal. “Nobody wins in a trade war, that is not in our national interest,” Starmer said.

Japan, America's closest ally in Asia, plans to closely analyze the U.S. tariffs and their impact, Chief Cabinet Secretary Yoshimasa Hayashi said, while refraining from talk of retaliation.

Financial markets were jolted, with U.S. stock futures down by as much as 3% early Thursday and a 2.8% drop in Tokyo’s benchmark leading losses in Asia. Oil prices sank more than $2 a barrel. Analysts fished for superlatives to a step that disrupts the global trading order and overturns decades of efforts to lower tariffs through trade talks and free trade agreements.

“The magnitude of the rollout — both in scale and speed — wasn’t just aggressive; it was a full-throttle macro disruption,” Stephen Innes of SPI Asset Management said in a commentary. Deutsche Bank's Jim Reid called it “radical policy reordering” and said the U.S. now had an average tariff of 25%-30%, the “worst end of expectations” and the highest since the early 20th Century.

“This is a game changer, not only for the U.S. economy but for the global economy. Many countries will likely end up in a recession,” Olu Sonola, Fitch Ratings’ head of U.S. Economic Research, said in a report. “You can throw most forecasts out the door, if this tariff rate stays on for an extended period of time.”

Asian countries that are among the biggest exporters to the U.S. pledged to act fast to support automakers and other businesses likely to be affected.

South Korean Prime Minister Han Duck-soo told officials to work with business groups to analyze the impact of the new 25% tariff to “minimize damage,” the trade ministry said.

China's Commerce Ministry said Beijing would “resolutely take countermeasures to safeguard its own rights and interests,” without saying exactly what it might do. With earlier rounds of tariffs China reacted by imposing higher duties on U.S. exports of farm products, while limiting exports of minerals used for high-tech industries such as electric vehicles.

Mexican President Claudia Sheinbaum said she would wait to see how Trump’s announcement will affect Mexico, which like Canada was spared for goods already qualified under their free trade agreement with the United States, though previously announced 25% tariffs on auto imports took effect Thursday.

A 29% tariff imposed on the tiny South Pacific outpost of Norfolk Island came as a shock. The Australian territory has a population of around 2,000 people and the economy revolves around tourism.

“To my knowledge, we do not export anything to the United States,” Norfolk Island Administrator George Plant, the Australian government’s representative on the island, told the AP on Thursday. “We don’t charge tariffs on anything. I can’t think of any non-tariff barriers that would be in place either, so we’re scratching our heads here.”

AP journalists around the world contributed to this story.