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NTx Announces Full Commercial Availability of NTxscribe to Broadly Enable RNA Therapies

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NTx Announces Full Commercial Availability of NTxscribe to Broadly Enable RNA Therapies
News

News

NTx Announces Full Commercial Availability of NTxscribe to Broadly Enable RNA Therapies

2025-01-09 22:01 Last Updated At:22:12

RIO RANCHO, N.M.--(BUSINESS WIRE)--Jan 9, 2025--

Nature’s Toolbox (NTx), a life sciences company developing next-generation platforms for RNA and protein manufacturing, today announced the full commercial availability of NTxscribe ®, a benchtop, continuous flow RNA in vitro transcription (IVT) and purification system that brings cost effective and scalable RNA manufacturing to the market.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250109963944/en/

Traditional RNA production methods are costly and complex. This slows clinical innovation, makes it hard to scale production to meet demand, and makes it nearly impossible to produce affordable personalized medicines. NTxscribe solves these challenges with a benchtop system that produces high-yield, high-integrity RNA in continuous flow and can scale seamlessly from small research doses to commercial volumes. NTxscribe produces 10-50 mg of high integrity RNA in two hours, shortening timelines for bringing new therapies and vaccines to market and empowering researchers, biotech, and pharmaceutical companies to make personalized medicine a reality.

“Our team has worked closely with NTx and utilized the innovative NTxscribe system for the last several years,” said John Cooke, MD, Ph.D., Medical Director of the RNA Therapeutics Program at the Houston Methodist DeBakey Heart and Vascular Center. “Through our partnership on a contract from Biomedical Advanced Research and Development Authority (BARDA), we were able to deliver exceptional results in demonstrating how NTxscribe can fulfill the need for a rapidly deployable RNA vaccine manufacturing capability. After seeing the final commercial product at NTx’s recent Scientific Advisory Board session, I believe we are seeing the future of how medicine will be delivered.”

NTxscribe’s small footprint enables rapid deployment even in mobile cleanrooms. Lower infrastructure costs make high-quality RNA production accessible to a wider range of organizations, including smaller labs and startups. NTxscribe also utilizes 100% U.S. made raw materials and enables an end-to-end domestic supply chain for critical biomaterials, in contrast to the current reality of profound dependence on China.

“Traditional biomanufacturing methods have not been able to keep pace with the surge in therapeutic innovation and rise of personalized medicine, and until now, there has not been a solution for the gaps in scalability and quality,” said Jamie Coffin, President and CEO at NTx. “Following our fully subscribed early access program with leading academic medical centers and major biopharma organizations, we are excited to bring NTxscribe to the broader market and help unlock the full potential of RNA therapies by enabling innovation for the future of medicine.”

To learn more about NTxscribe and how NTx can help address different biomanufacturing needs, please schedule a design session here: https://ntxbio.com/reserve.

About NTx

Nature’s Toolbox, Inc. (NTx), based in Rio Rancho, New Mexico, is revolutionizing biomanufacturing with cutting-edge solutions tailored to the demands of modern research and personalized medicine. NTx is developing innovative systems like NTxscribe® and NTxpress® to enable the sustainable production of mRNA and protein therapeutics, offering scalability from personalized doses to mass-market volumes. Discover how NTx is shaping the future of medicine at www.ntxbio.com.

NTx announced the full commercial availability of NTxscribe®, a benchtop, continuous flow RNA in vitro transcription (IVT) and purification system that brings cost effective and scalable RNA manufacturing to the market. (Photo: Business Wire)

NTx announced the full commercial availability of NTxscribe®, a benchtop, continuous flow RNA in vitro transcription (IVT) and purification system that brings cost effective and scalable RNA manufacturing to the market. (Photo: Business Wire)

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Myanmar earthquake death toll rises to 3,085 as more bodies found

2025-04-03 16:46 Last Updated At:16:51

BANGKOK (AP) — The death toll from the massive earthquake that hit Myanmar nearly a week ago rose Thursday to 3,085 as search and rescue teams found more bodies, the military-led government said, and humanitarian aid groups scrambled to provide survivors medical care and shelter.

In a short statement, the military said another 4,715 people have been injured and 341 are missing.

The epicenter of Friday's 7.7 magnitude earthquake was near Mandalay, Myanmar's second-largest city. It brought down thousands of buildings, buckled roads and destroyed bridges in multiple regions.

Local media reports of casualties have been much higher than the official figures and with telecommunications widely out and many places difficult to reach, it's thought the numbers could rise sharply as more details come in.

The World Health Organization said that according to its initial assessment, four hospitals and one health center had been completely destroyed while another 32 hospitals and 18 health centers had been partially damaged.

“With infrastructure compromised and patient numbers surging, access to health care has become nearly impossible in many of the worst-hit areas,” the U.N. said. “Thousands of people are in urgent need of trauma care, surgical interventions and treatment for disease outbreaks.”

A mobile hospital from India and a joint Russian-Belarusian hospital also were now operating in Mandalay.

With many left homeless by the earthquake, and many others staying away from their homes over fears ongoing aftershocks will bring them down, workers in Naypyitaw labored in the 40 degree Celsius (104 degrees Fahrenheit) busily erected big tents in open fields to provide some shelter.

Myanmar’s military seized power in 2021 from the democratically elected government of Aung San Suu Kyi, sparking what has turned into a civil war.

The quake worsened an already dire humanitarian crisis, with more than 3 million people displaced from their homes and nearly 20 million in need even before it hit, according to the United Nations.

As concerns grew that ongoing fighting could hamper humanitarian aid efforts, the military declared a temporary ceasefire Wednesday, through April 22. The announcement followed unilateral temporary ceasefires announced by armed resistance groups opposed to military rule.

The military said it would still take “necessary” measures against those groups if they use the ceasefire to regroup, train or launch attacks.

Already on Thursday there were reports from local media in Kachin state in the north of Myanmar that military attacks continued in several areas, but they could not be independently confirmed. Prior to the earthquake the military was battling the Kachin Independence Army militia group. The earthquake shook Kachin, but there have been no reports of damage there.

In Bangkok, where the quake brought down a skyscraper under construction, the search for survivors and bodies continued as Gov. Chadchart Sittipunt said a possible sound of life was detected in the rubble. By mid-afternoon, more than 144 hours after the earthquake, nobody had been found.

Twenty-two people were killed and 35 injured in the city, mostly by the collapse of the unfinished building.

Associated Press writer Jintamas Saksornchai contributed to this report.

Rescuers carry the body of a victim, from a collapsed building in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescuers carry the body of a victim, from a collapsed building in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescuers carry the body of a victim, from a collapsed building in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescuers carry the body of a victim, from a collapsed building in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescue members carry a dead body from a collapsed building in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescue members carry a dead body from a collapsed building in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescuers carry the body of a victim, from a collapsed building, in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescuers carry the body of a victim, from a collapsed building, in the aftermath of Friday's earthquake in Mandalay, Myanmar, Thursday, April 3, 2025. (AP Photo)

Rescuers scan the rubbles at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Wednesday, April 2, 2025. (AP Photo/Manish Swarup)

Rescuers scan the rubbles at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Wednesday, April 2, 2025. (AP Photo/Manish Swarup)

Rescuers manually clear the rubble after getting a sign of life at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Rescuers manually clear the rubble after getting a sign of life at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Rescuers return after accessing the situation at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Rescuers return after accessing the situation at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Rescuers manually clear the rubble after getting a sign of life at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Rescuers manually clear the rubble after getting a sign of life at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Rescuers manually clear the rubble after getting a sign of life at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Rescuers manually clear the rubble after getting a sign of life at the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Workers clean and wash the road outside the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

Workers clean and wash the road outside the site of an under construction high-rise building that collapsed after an earthquake in Bangkok, Thailand, Thursday, April, 3, 2025. (AP Photo/Manish Swarup)

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