RIO RANCHO, N.M.--(BUSINESS WIRE)--Jan 9, 2025--
Nature’s Toolbox (NTx), a life sciences company developing next-generation platforms for RNA and protein manufacturing, today announced the full commercial availability of NTxscribe ®, a benchtop, continuous flow RNA in vitro transcription (IVT) and purification system that brings cost effective and scalable RNA manufacturing to the market.
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Traditional RNA production methods are costly and complex. This slows clinical innovation, makes it hard to scale production to meet demand, and makes it nearly impossible to produce affordable personalized medicines. NTxscribe solves these challenges with a benchtop system that produces high-yield, high-integrity RNA in continuous flow and can scale seamlessly from small research doses to commercial volumes. NTxscribe produces 10-50 mg of high integrity RNA in two hours, shortening timelines for bringing new therapies and vaccines to market and empowering researchers, biotech, and pharmaceutical companies to make personalized medicine a reality.
“Our team has worked closely with NTx and utilized the innovative NTxscribe system for the last several years,” said John Cooke, MD, Ph.D., Medical Director of the RNA Therapeutics Program at the Houston Methodist DeBakey Heart and Vascular Center. “Through our partnership on a contract from Biomedical Advanced Research and Development Authority (BARDA), we were able to deliver exceptional results in demonstrating how NTxscribe can fulfill the need for a rapidly deployable RNA vaccine manufacturing capability. After seeing the final commercial product at NTx’s recent Scientific Advisory Board session, I believe we are seeing the future of how medicine will be delivered.”
NTxscribe’s small footprint enables rapid deployment even in mobile cleanrooms. Lower infrastructure costs make high-quality RNA production accessible to a wider range of organizations, including smaller labs and startups. NTxscribe also utilizes 100% U.S. made raw materials and enables an end-to-end domestic supply chain for critical biomaterials, in contrast to the current reality of profound dependence on China.
“Traditional biomanufacturing methods have not been able to keep pace with the surge in therapeutic innovation and rise of personalized medicine, and until now, there has not been a solution for the gaps in scalability and quality,” said Jamie Coffin, President and CEO at NTx. “Following our fully subscribed early access program with leading academic medical centers and major biopharma organizations, we are excited to bring NTxscribe to the broader market and help unlock the full potential of RNA therapies by enabling innovation for the future of medicine.”
To learn more about NTxscribe and how NTx can help address different biomanufacturing needs, please schedule a design session here: https://ntxbio.com/reserve.
About NTx
Nature’s Toolbox, Inc. (NTx), based in Rio Rancho, New Mexico, is revolutionizing biomanufacturing with cutting-edge solutions tailored to the demands of modern research and personalized medicine. NTx is developing innovative systems like NTxscribe® and NTxpress® to enable the sustainable production of mRNA and protein therapeutics, offering scalability from personalized doses to mass-market volumes. Discover how NTx is shaping the future of medicine at www.ntxbio.com.
NTx announced the full commercial availability of NTxscribe®, a benchtop, continuous flow RNA in vitro transcription (IVT) and purification system that brings cost effective and scalable RNA manufacturing to the market. (Photo: Business Wire)
WASHINGTON (AP) — Lawyers for accused 9/11 mastermind Khalid Sheikh Mohammed are urging a federal appeals panel to let his scheduled guilty plea Friday in Guantanamo Bay, Cuba, go forward in a plea agreement that would spare him and two co-defendants the risk of the death penalty in al-Qaida's notorious Sept. 11, 2001, attacks.
Defense lawyers in a filing late Wednesday described Defense Secretary Lloyd Austin's attempts to throw out a plea deal that his own military had negotiated and approved as the latest in two decades of “fitful" and “negligent” mishandling of the case by the U.S. military and successive administrations.
Mohammed is due to enter his plea Friday morning in the attacks, in which 19 al-Qaida hijackers smashed airliners into the World Trade Center and the Pentagon and another crashed into a Pennsylvania field, killing nearly 3,000 people. Family members of some of the victims are gathered at Guantanamo for the moment.
Austin unexpectedly renounced the plea agreement after it was announced this summer, and the Biden administration's Justice Department is seeking to block Mohammed's plea from going forward at a U.S. military commission courtroom.
“An 11th-hour stay will accomplish nothing but more delay and it will reward the government for its — at best — negligent handling” of the 9/11 prosecutions, Mohammed's lawyers argued in a filing to a District of Columbia federal appeals panel just before midnight.
The federal appeals panel appears on track to possibly rule Thursday on the request by the Democratic Biden administration.
Legal and logistical challenges have bogged down the 9/11 case in the 17 years since Mohammed, who prosecutors say conceived the idea of using hijacked planes in the attacks, was first charged. The case remains in pre-trial hearings, with no trial date set.
Years of defense and prosecution testimony are ongoing about how much the sustained torture of Mohammed and other defendants in CIA custody renders their later statements legally inadmissible.
With the prosecution in the Sept. 11 attacks dragging on for decades and no conclusion in sight, military prosecutors this summer notified families of the victims that the senior Pentagon official overseeing Guantanamo had approved a plea deal after more than two years of negotiations.
The deal was “the best path to finality and justice,” military prosecutors told families then. In it, Mohammed and co-defendants Walid bin Attash and Mustafa al-Hawsawi agreed to plead guilty to 2,976 murder charges in exchange for life sentences.
Austin unexpectedly announced Aug. 2 that he was nullifying the plea deal, and he has fought since then to scrap it. He argues that a decision on death penalties in an attack as grave as Sept. 11 should only be made by the defense secretary.
Defense attorneys say that the plea agreement is already in effect and that Austin has no legal standing to throw it out after the fact. The Biden administration went to the federal appeals court Tuesday after the Guantanamo judge and a military review panel sided against Austin's request.
Mohammed's attorneys argued in the new filing that Austin's “extraordinary intervention in this case is solely a product of his lack of oversight over his own duly appointed delegate,” meaning the senior Pentagon official overseeing Guantanamo.
The Justice Department's brief earlier this week said that the government would be irreparably harmed if the guilty pleas were accepted for Mohammed and the two co-defendants in the Sept. 11 attacks.
It said the government would be denied a chance for a public trial and the opportunity to “seek capital punishment against three men charged with a heinous act of mass murder that caused the death of thousands of people and shocked the nation and the world.”
FILE - In this April 17, 2019, photo, reviewed by U.S. military officials, the control tower is seen through the razor wire inside the Camp VI detention facility in Guantanamo Bay Naval Base, Cuba. (AP Photo/Alex Brandon, File)
FILE - US Secretary of Defence Lloyd Austin makes a speech at Diplomatic Academy of Ukraine in Kyiv, Ukraine, Monday, Oct. 21, 2024. (AP Photo/Efrem Lukatsky, File)
FILE - This Monday, Dec. 8, 2008 courtroom drawing by artist Janet Hamlin and reviewed by the U.S. military, shows Khalid Sheikh Mohammed, center, and co-defendant Walid Bin Attash, left, attending a pre-trial session at Guantanamo Bay Naval Base, Cuba. (AP Photo/Janet Hamlin, Pool, File)
